Abstract
Ten patients with severe neurological disease that was clinically indistinguishable from subacute combined degeneration of the spinal cord were found to have normal serum vitamin B12 levels. All were folate deficient. Specific folate treatment led to significant reversal of the neuropathy. These findings indicate the need to review orthodox concepts of the role of folic acid in maintaining the integrity of the nervous system.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arakawa T. Congenital defects in folate utilization. Am J Med. 1970 May;48(5):594–598. doi: 10.1016/0002-9343(70)90009-4. [DOI] [PubMed] [Google Scholar]
- CHANARIN I., ROTHMAN D., BERRY V. IRON DEFICIENCY AND ITS RELATION TO FOLIC-ACID STATUS IN PREGNANCY: RESULTS OF A CLINICAL TRIAL. Br Med J. 1965 Feb 20;1(5433):480–485. doi: 10.1136/bmj.1.5433.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COOPER B. A., LOWENSTEIN L. RELATIVE FOLATE DEFICIENCY OF ERYTHROCYTES IN PERNICIOUS ANEMIA AND ITS CORRECTION WITH CYANOCOBALAMIN. Blood. 1964 Nov;24:502–521. [PubMed] [Google Scholar]
- Freeman J. M., Finkelstein J. D., Mudd S. H. Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med. 1975 Mar 6;292(10):491–496. doi: 10.1056/NEJM197503062921001. [DOI] [PubMed] [Google Scholar]
- Horwitz S. J., Klipstein F. A., Lovelace R. E. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Lancet. 1968 Mar 16;1(7542):563–565. doi: 10.1016/s0140-6736(68)92832-8. [DOI] [PubMed] [Google Scholar]
- Melamed E., Reches A., Hershko C. Reversible central nervous system dysfunction in folate deficiency. J Neurol Sci. 1975 May;25(1):93–98. doi: 10.1016/0022-510x(75)90189-6. [DOI] [PubMed] [Google Scholar]
- Pincus J. H., Reynolds E. H., Glaser G. H. Subacute combined system degeneration with folate deficiency. JAMA. 1972 Jul 31;221(5):496–497. [PubMed] [Google Scholar]
- Read A. E., Gough K. R., Pardoe J. L., Nicholas A. Nutritional studies on the entrants to an old people's home, with particular reference to folic-acid deficiency. Br Med J. 1965 Oct 9;2(5466):843–848. doi: 10.1136/bmj.2.5466.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wells D. G., Casey H. J. Lactobacillus casei C.S.F. folate activity. Br Med J. 1967 Sep 30;3(5569):834–836. doi: 10.1136/bmj.3.5569.834. [DOI] [PMC free article] [PubMed] [Google Scholar]