Abstract
The antihypertensive effect of labetalol, a new alpha- and beta-adrenoceptor inhibiting agent, was studied in 20 patients in a double-blind crossover trial. A dose of 300 mg daily reduced blood pressure only moderately in the supine position, though in the sitting and standing positions the effect was more pronounced. A dose of 600 mg daily produced statistically significant and clinically relevant reductions in blood pressure in all positions studied. The effect on heart rate was small and of significance only in reducing the heart rate increment due to a change in posture. Side effects were mild: only one patient complained of postural dizziness with the higher dose. We conclude that labetalol is useful in the treatment of mild and moderately severe hypertension.
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Selected References
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- Collier J. G., Dawnay N. A., Nachev C., Robinson B. F. Clinical investigation of an antagonist at alpha- and beta-adrenoceptors-AH5158A. Br J Pharmacol. 1972 Feb;44(2):286–293. doi: 10.1111/j.1476-5381.1972.tb07265.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farmer J. B., Kennedy I., Levy G. P., Marshall R. J. Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors. Br J Pharmacol. 1972 Aug;45(4):660–675. doi: 10.1111/j.1476-5381.1972.tb08125.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frohlich E. D., Tarazi R. C., Dustan H. P., Page I. H. The paradox of beta-adrenergic blockade in hypertension. Circulation. 1968 Mar;37(3):417–423. doi: 10.1161/01.cir.37.3.417. [DOI] [PubMed] [Google Scholar]
- Furberg C., Michaelson G. Effect of aptin, a beta-adrenergic blocking agent, in arterial hypertension. Acta Med Scand. 1969 Nov;186(5):447–450. doi: 10.1111/j.0954-6820.1969.tb01501.x. [DOI] [PubMed] [Google Scholar]
- Hansson L., Malmcrona R., Olander R., Rosenhall L., Westerlund A., Aberg H., Hood B. Propranolol in hypertension. Report on 158 patients treated up to one year. Klin Wochenschr. 1972 Apr 1;50(7):364–369. doi: 10.1007/BF01486832. [DOI] [PubMed] [Google Scholar]
- Hansson L., Zweifler A. J., Julius S., Hunyor S. N. Hemodynamic effects of acute and prolonged beta-adrenergic blockade in essential hypertension. Acta Med Scand. 1974 Jul-Aug;196(1-2):27–34. doi: 10.1111/j.0954-6820.1974.tb00962.x. [DOI] [PubMed] [Google Scholar]
- Katila M., Frick M. H. Combined dihydralazine and propranolol in the treatment of hypertension. Int Z Klin Pharmakol Ther Toxikol. 1970 Dec;4(1):111–114. [PubMed] [Google Scholar]
- Kennedy I., Levy G. P. Combined alpha- and beta-adrenoceptor blocking drug AH 5158: further studies on alpha-adrenoceptor blockade in anaesthetized animals. Br J Pharmacol. 1975 Apr;53(4):585–592. doi: 10.1111/j.1476-5381.1975.tb07398.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lydtin H., Kusus T., Daniel W., Schierl W., Ackenheil M., Kempter H., Lohmöller G., Niklas M., Walter I. Propranolol therapy in essential hypertension. Am Heart J. 1972 May;83(5):589–595. doi: 10.1016/0002-8703(72)90397-3. [DOI] [PubMed] [Google Scholar]
- Prichard B. N., Gillam P. M. Treatment of hypertension with propranolol. Br Med J. 1969 Jan 4;1(5635):7–16. doi: 10.1136/bmj.1.5635.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prichard B. N., Shinebourne E., Fleming J., Hamer J. Haemodynamic studies in hypertensive patients treated by oral proranolol. Br Heart J. 1970 Mar;32(2):236–240. doi: 10.1136/hrt.32.2.236. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Skinner C., Gaddie J., Palmer K. N. Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59–61. doi: 10.1136/bmj.2.5962.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tarazi R. C., Dustan H. P. Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations. Am J Cardiol. 1972 May;29(5):633–640. doi: 10.1016/0002-9149(72)90164-6. [DOI] [PubMed] [Google Scholar]