Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1997 Aug;41(8):1815–1817. doi: 10.1128/aac.41.8.1815

Guinea pig model for Staphylococcus aureus native valve endocarditis.

M Maurin 1, H Lepidi 1, B La Scola 1, M Feuerstein 1, M Andre 1, J F Pellissier 1, D Raoult 1
PMCID: PMC164013  PMID: 9257769

Abstract

We present a new experimental model of Staphylococcus aureus infective endocarditis in guinea pigs. Permanent aortic valve damage was produced by electrocoagulation after catheterization of the right carotid artery, which allowed avoidance of the intracardiac catheter to produce cardiac vegetations. Our model closely mimics pathological mechanisms of native valve endocarditis.

Full Text

The Full Text of this article is available as a PDF (715.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
  2. Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
  3. Francioli P. B., Freedman L. R. Streptococcal infection of endocardial and other intravascular vegetations in rabbits: natural history and effect of dexamethasone. Infect Immun. 1979 May;24(2):483–491. doi: 10.1128/iai.24.2.483-491.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Freedman L. R., Valone J., Jr Experimental infective endocarditis. Prog Cardiovasc Dis. 1979 Nov-Dec;22(3):169–180. doi: 10.1016/0033-0620(79)90021-5. [DOI] [PubMed] [Google Scholar]
  5. Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
  6. Glauser M. P., Francioli P. Relevance of animal models to the prophylaxis of infective endocarditis. J Antimicrob Chemother. 1987 Sep;20 (Suppl A):87–98. doi: 10.1093/jac/20.suppl_a.87. [DOI] [PubMed] [Google Scholar]
  7. Greenberg D. P., Ward J. I., Bayer A. S. Influence of Staphylococcus aureus antibody on experimental endocarditis in rabbits. Infect Immun. 1987 Dec;55(12):3030–3034. doi: 10.1128/iai.55.12.3030-3034.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Héraïef E., Glauser M. P., Freedman L. R. Natural history of aortic valve endocarditis in rats. Infect Immun. 1982 Jul;37(1):127–131. doi: 10.1128/iai.37.1.127-131.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pelletier L. L., Jr, Petersdorf R. G., Nielson K. Chemotherapy of experimental streptococcal endocarditis. V. Effect of duration of infection and retained intracardiac catheter on response to treatment. J Lab Clin Med. 1976 Apr;87(4):692–702. [PubMed] [Google Scholar]
  10. Perlman B. B., Freedman L. R. Experimental endocarditis. 3. Natural history of catheter induced staphylococcal endocarditis following catheter removal. Yale J Biol Med. 1971 Oct;44(2):214–224. [PMC free article] [PubMed] [Google Scholar]
  11. Perlman B. B., Freedman L. R. Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. Yale J Biol Med. 1971 Oct;44(2):206–213. [PMC free article] [PubMed] [Google Scholar]
  12. Petersdorf R. G. Antimicrobial prophylaxis of bacterial endocarditis. Prudent caution or bacterial overkill? Am J Med. 1978 Aug;65(2):220–223. doi: 10.1016/0002-9343(78)90811-2. [DOI] [PubMed] [Google Scholar]
  13. Santoro J., Levison M. E. Rat model of experimental endocarditis. Infect Immun. 1978 Mar;19(3):915–918. doi: 10.1128/iai.19.3.915-918.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sipes J. N., Thompson R. L., Hook E. W. Prophylaxis of infective endocarditis: a reevaluation. Annu Rev Med. 1977;28:371–391. doi: 10.1146/annurev.me.28.020177.002103. [DOI] [PubMed] [Google Scholar]
  15. Yersin B., Glauser M. P., Guze P. A., Guze L. B., Freedman L. R. Experimental Escherichia coli endocarditis in rats: roles of serum bactericidal activity and duration of catheter placement. Infect Immun. 1988 May;56(5):1273–1280. doi: 10.1128/iai.56.5.1273-1280.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES