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. 1997 Sep;41(9):2009–2012. doi: 10.1128/aac.41.9.2009

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.

K K Wong 1, K Poole 1, N Gotoh 1, R E Hancock 1
PMCID: PMC164054  PMID: 9303403

Abstract

MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.

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Selected References

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