Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1997 Sep;41(9):2037–2040. doi: 10.1128/aac.41.9.2037

Comparative susceptibilities of various animal-pathogenic mycoplasmas to fluoroquinolones.

P C Hannan 1, G D Windsor 1, A de Jong 1, N Schmeer 1, M Stegemann 1
PMCID: PMC164063  PMID: 9303412

Abstract

The in vitro activities of six antimicrobial agents were tested against 162 mycoplasma strains of eight species isolated from poultry and livestock at different geographic sites. Tiamulin was most active (MICs at which 90% of the isolates were inhibited [MIC90s], 0.025 to 0.25 microg/ml); enrofloxacin and danofloxacin had near equivalent activities (MIC90s, 0.05 to 1.0 microg/ml), but were much more active than flumequine (MIC90s, 1 to 50 microg/ml). The MIC90s of tylosin and oxytetracycline were 0.25 to > 100 microg/ml and 0.25 to 100 microg/ml, respectively.

Full Text

The Full Text of this article is available as a PDF (171.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cooper A. C., Fuller J. R., Fuller M. K., Whittlestone P., Wise D. R. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. Res Vet Sci. 1993 May;54(3):329–334. doi: 10.1016/0034-5288(93)90130-8. [DOI] [PubMed] [Google Scholar]
  2. Devriese L. A., Haesebrouck F. Antibiotic susceptibility testing of Mycoplasma bovis using Tween 80 hydrolysis as an indicator of growth. Zentralbl Veterinarmed B. 1991 Dec;38(10):781–783. doi: 10.1111/j.1439-0450.1991.tb00943.x. [DOI] [PubMed] [Google Scholar]
  3. Friis N. F., Szancer J. Sensitivity of certain porcine and bovine mycoplasmas to antimicrobial agents in a liquid medium test compared to a disc assay. Acta Vet Scand. 1994;35(4):389–394. doi: 10.1186/BF03548313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hannan P. C., O'Hanlon P. J., Rogers N. H. In vitro evaluation of various quinolone antibacterial agents against veterinary mycoplasmas and porcine respiratory bacterial pathogens. Res Vet Sci. 1989 Mar;46(2):202–211. [PubMed] [Google Scholar]
  5. Inamoto T., Takahashi H., Yamamoto K., Nakai Y., Ogimoto K. Antibiotic susceptibility of Mycoplasma hyopneumoniae isolated from swine. J Vet Med Sci. 1994 Apr;56(2):393–394. doi: 10.1292/jvms.56.393. [DOI] [PubMed] [Google Scholar]
  6. Kobayashi H., Morozumi T., Munthali G., Mitani K., Ito N., Yamamoto K. Macrolide susceptibility of Mycoplasma hyorhinis isolated from piglets. Antimicrob Agents Chemother. 1996 Apr;40(4):1030–1032. doi: 10.1128/aac.40.4.1030. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kobayashi H., Sonmez N., Morozumi T., Mitani K., Ito N., Shiono H., Yamamoto K. In vitro susceptibility of Mycoplasma hyosynoviae and M. hyorhinis to antimicrobial agents. J Vet Med Sci. 1996 Nov;58(11):1107–1111. doi: 10.1292/jvms.58.11_1107. [DOI] [PubMed] [Google Scholar]
  8. Levisohn S. Antibiotic sensitivity patterns in field isolates of Mycoplasma gallisepticum as a guide to chemotherapy. Isr J Med Sci. 1981 Jul;17(7):661–666. [PubMed] [Google Scholar]
  9. Poumarat F., Martel J. L. Antibiosensibilité in vitro des souches françaises de Mycoplasma bovis. Ann Rech Vet. 1989;20(2):145–152. [PubMed] [Google Scholar]
  10. Ross R. F., Young T. F. The nature and detection of mycoplasmal immunogens. Vet Microbiol. 1993 Nov;37(3-4):369–380. doi: 10.1016/0378-1135(93)90035-6. [DOI] [PubMed] [Google Scholar]
  11. Takahashi I., Yoshida T. [Antimycoplasmal activities of ofloxacin and commonly used antimicrobial agents on Mycoplasma gallisepticum]. Jpn J Antibiot. 1989 May;42(5):1166–1172. [PubMed] [Google Scholar]
  12. Tanner A. C., Wu C. C. Adaptation of the Sensititre broth microdilution technique to antimicrobial susceptibility testing of Mycoplasma gallisepticum. Avian Dis. 1992 Jul-Sep;36(3):714–717. [PubMed] [Google Scholar]
  13. Ter Laak E. A., Pijpers A., Noordergraaf J. H., Schoevers E. C., Verheijden J. H. Comparison of methods for in vitro testing of susceptibility of porcine Mycoplasma species to antimicrobial agents. Antimicrob Agents Chemother. 1991 Feb;35(2):228–233. doi: 10.1128/aac.35.2.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Woodcock J. M., Andrews J. M., Boswell F. J., Brenwald N. P., Wise R. In vitro activity of BAY 12-8039, a new fluoroquinolone. Antimicrob Agents Chemother. 1997 Jan;41(1):101–106. doi: 10.1128/aac.41.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Zimmermann B. J., Ross R. F. Determination of sensitivity of Mycoplasma hyosynoviae to tylosin and selected antibacterial drugs by a microtiter technique. Can J Comp Med. 1975 Jan;39(1):17–21. [PMC free article] [PubMed] [Google Scholar]
  16. ter Laak E. A., Noordergraaf J. H., Verschure M. H. Susceptibilities of Mycoplasma bovis, Mycoplasma dispar, and Ureaplasma diversum strains to antimicrobial agents in vitro. Antimicrob Agents Chemother. 1993 Feb;37(2):317–321. doi: 10.1128/aac.37.2.317. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES