Abstract
This study examined if complexation with metals increased the antiproliferative activities of chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class. Addition of iron(III) to some PIH analogs markedly depressed their activities, whereas it had little effect on others. The gallium(III) complex of PIH, but not its copper(II) complex, was more efficient than the apochelator at inhibiting [3H]thymidine incorporation.
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- Becton D. L., Bryles P. Deferoxamine inhibition of human neuroblastoma viability and proliferation. Cancer Res. 1988 Dec 15;48(24 Pt 1):7189–7192. [PubMed] [Google Scholar]
- Becton D. L., Roberts B. Antileukemic effects of deferoxamine on human myeloid leukemia cell lines. Cancer Res. 1989 Sep 1;49(17):4809–4812. [PubMed] [Google Scholar]
- Burger R. M., Peisach J., Horwitz S. B. Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. J Biol Chem. 1981 Nov 25;256(22):11636–11644. [PubMed] [Google Scholar]
- Donfrancesco A., Deb G., Dominici C., Pileggi D., Castello M. A., Helson L. Effects of a single course of deferoxamine in neuroblastoma patients. Cancer Res. 1990 Aug 15;50(16):4929–4930. [PubMed] [Google Scholar]
- Estrov Z., Tawa A., Wang X. H., Dubé I. D., Sulh H., Cohen A., Gelfand E. W., Freedman M. H. In vitro and in vivo effects of deferoxamine in neonatal acute leukemia. Blood. 1987 Mar;69(3):757–761. [PubMed] [Google Scholar]
- Kontoghiorghes G. J., Piga A., Hoffbrand A. V. Cytotoxic effects of the lipophilic iron chelator omadine. FEBS Lett. 1986 Aug 18;204(2):208–212. doi: 10.1016/0014-5793(86)80813-4. [DOI] [PubMed] [Google Scholar]
- Richardson D. R., Baker E. The uptake of iron and transferrin by the human malignant melanoma cell. Biochim Biophys Acta. 1990 Jun 12;1053(1):1–12. doi: 10.1016/0167-4889(90)90018-9. [DOI] [PubMed] [Google Scholar]
- Richardson D. R., Hefter G. T., May P. M., Webb J., Baker E. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II) and zinc(II). Biol Met. 1989;2(3):161–167. doi: 10.1007/BF01142555. [DOI] [PubMed] [Google Scholar]
- Richardson D. R., Milnes K. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood. 1997 Apr 15;89(8):3025–3038. [PubMed] [Google Scholar]
- Richardson D. R., Ponka P. The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. J Lab Clin Med. 1994 Nov;124(5):660–671. [PubMed] [Google Scholar]
- Richardson D. R., Tran E. H., Ponka P. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents. Blood. 1995 Dec 1;86(11):4295–4306. [PubMed] [Google Scholar]
- Seligman P. A., Schleicher R. B., Siriwardana G., Domenico J., Gelfand E. W. Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation. Blood. 1993 Sep 1;82(5):1608–1617. [PubMed] [Google Scholar]
- Singh S., Hider R. C. Colorimetric detection of the hydroxyl radical: comparison of the hydroxyl-radical-generating ability of various iron complexes. Anal Biochem. 1988 May 15;171(1):47–54. doi: 10.1016/0003-2697(88)90123-6. [DOI] [PubMed] [Google Scholar]
- Thelander L., Gräslund A. Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction. J Biol Chem. 1983 Apr 10;258(7):4063–4066. [PubMed] [Google Scholar]