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. 1997 Oct;41(10):2289–2291. doi: 10.1128/aac.41.10.2289

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.

M Nakano 1, T Deguchi 1, T Kawamura 1, M Yasuda 1, M Kimura 1, Y Okano 1, Y Kawada 1
PMCID: PMC164110  PMID: 9333065

Abstract

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

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Selected References

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