Abstract
The in vitro activities of 10 antimicrobial agents against 159 bacterial vaginosis-associated anaerobic isolates from pregnant Japanese and Thai women were determined. Clindamycin, imipenem, cefmetazole, amoxicillin, amoxicillin-clavulanate, and metronidazole were highly active against all anaerobic isolates except Prevotella bivia and Mobiluncus species, which were resistant to amoxicillin and metronidazole, respectively. Cefotiam, ceftazidime, and ofloxacin were variably effective, while cefaclor was the least effective agent.
Full Text
The Full Text of this article is available as a PDF (129.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brook I. The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev Infect Dis. 1984 Sep-Oct;6(5):601–607. doi: 10.1093/clinids/6.5.601. [DOI] [PubMed] [Google Scholar]
- Duff P., Lee M. L., Hillier S. L., Herd L. M., Krohn M. A., Eschenbach D. A. Amoxicillin treatment of bacterial vaginosis during pregnancy. Obstet Gynecol. 1991 Mar;77(3):431–435. [PubMed] [Google Scholar]
- Holst E., Goffeng A. R., Andersch B. Bacterial vaginosis and vaginal microorganisms in idiopathic premature labor and association with pregnancy outcome. J Clin Microbiol. 1994 Jan;32(1):176–186. doi: 10.1128/jcm.32.1.176-186.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martius J., Eschenbach D. A. The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity--a review. Arch Gynecol Obstet. 1990;247(1):1–13. doi: 10.1007/BF02390649. [DOI] [PubMed] [Google Scholar]
- McGregor J. A., French J. I., Parker R., Draper D., Patterson E., Jones W., Thorsgard K., McFee J. Prevention of premature birth by screening and treatment for common genital tract infections: results of a prospective controlled evaluation. Am J Obstet Gynecol. 1995 Jul;173(1):157–167. doi: 10.1016/0002-9378(95)90184-1. [DOI] [PubMed] [Google Scholar]
- McGregor J. A., French J. I., Richter R., Franco-Buff A., Johnson A., Hillier S., Judson F. N., Todd J. K. Antenatal microbiologic and maternal risk factors associated with prematurity. Am J Obstet Gynecol. 1990 Nov;163(5 Pt 1):1465–1473. doi: 10.1016/0002-9378(90)90607-9. [DOI] [PubMed] [Google Scholar]
- Puapermpoonsiri S., Kato N., Watanabe K., Ueno K., Chongsomchai C., Lumbiganon P. Vaginal microflora associated with bacterial vaginosis in Japanese and Thai pregnant women. Clin Infect Dis. 1996 Oct;23(4):748–752. doi: 10.1093/clinids/23.4.748. [DOI] [PubMed] [Google Scholar]
- Sweet R. L. New approaches for the treatment of bacterial vaginosis. Am J Obstet Gynecol. 1993 Aug;169(2 Pt 2):479–482. doi: 10.1016/0002-9378(93)90346-k. [DOI] [PubMed] [Google Scholar]