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. 1997 Oct;41(10):2305–2307. doi: 10.1128/aac.41.10.2305

In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.

A Valentin 1, F Benoit-Vical 1, C Moulis 1, E Stanislas 1, M Mallié 1, I Fouraste 1, J M Bastide 1
PMCID: PMC164116  PMID: 9333071

Abstract

Two bisbenzylisoquinolines, tetrandrine and penduline, were purified from Isopyrum thalictroides. When tested for antimalarial activity in vitro, penduline was efficient at concentrations fivefold lower than those of tetrandrine. In highly synchronized parasite cultures, penduline mostly interfered between the 8th and the 32nd hours of the parasite cycle.

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Selected References

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