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. 1997 Nov;41(11):2448–2455. doi: 10.1128/aac.41.11.2448

Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats.

D L Kordick 1, M G Papich 1, E B Breitschwerdt 1
PMCID: PMC164143  PMID: 9371348

Abstract

Enrofloxacin and doxycycline are antimicrobial agents used to treat bacterial diseases of cats. In vitro susceptibility data indicate that either drug should be effective against Bartonella species. In vivo efficacies of these drugs for eradication of chronic Bartonella henselae or Bartonella clarridgeiae infections were examined in 18 experimentally infected cats and 25 naturally exposed cats treated with enrofloxacin (22.7 mg given orally [PO] every 12 h [q12h] [14 days, n = 10; 28 days, n = 13]) or with doxycycline (25 mg PO q12h [14 days, n = 9; 28 days, n = 8]) or not treated (n = 3). Plasma drug concentrations were determined in experimental cats by high-performance liquid chromatography. Only 23 of 43 cats enrolled ultimately met inclusion criteria. Bacteremia was eliminated for 12 to 25 weeks posttreatment in four of seven cats receiving 14 days of enrofloxacin, five of seven cats receiving 28 days of enrofloxacin, one of six cats receiving 14 days of doxycycline, and one of two cats receiving 28 days of doxycycline. Defining a negative result by blood culture as treatment success may be erroneous; these results may reflect the insensitivity of blood culture or the relapsing nature of Bartonella bacteremia. Our results suggest that MICs obtained with axenic media do not predict antimicrobial activity against intracellular Bartonella, that a long treatment course is required to eliminate infection, and that duration of therapy correlates with pretreatment bacterial load. Given current concern about the development of antimicrobial resistance, we would reserve recommendation for treatment to cats owned by an immunocompromised individual or as an alternative to euthanasia of a pet.

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Selected References

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  1. Anderson B. E., Neuman M. A. Bartonella spp. as emerging human pathogens. Clin Microbiol Rev. 1997 Apr;10(2):203–219. doi: 10.1128/cmr.10.2.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bogue C. W., Wise J. D., Gray G. F., Edwards K. M. Antibiotic therapy for cat-scratch disease? JAMA. 1989 Aug 11;262(6):813–816. [PubMed] [Google Scholar]
  3. Breitschwerdt E. B., Kordick D. L., Malarkey D. E., Keene B., Hadfield T. L., Wilson K. Endocarditis in a dog due to infection with a novel Bartonella subspecies. J Clin Microbiol. 1995 Jan;33(1):154–160. doi: 10.1128/jcm.33.1.154-160.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chomel B. B., Abbott R. C., Kasten R. W., Floyd-Hawkins K. A., Kass P. H., Glaser C. A., Pedersen N. C., Koehler J. E. Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers. J Clin Microbiol. 1995 Sep;33(9):2445–2450. doi: 10.1128/jcm.33.9.2445-2450.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chomel B. B., Kasten R. W., Floyd-Hawkins K., Chi B., Yamamoto K., Roberts-Wilson J., Gurfield A. N., Abbott R. C., Pedersen N. C., Koehler J. E. Experimental transmission of Bartonella henselae by the cat flea. J Clin Microbiol. 1996 Aug;34(8):1952–1956. doi: 10.1128/jcm.34.8.1952-1956.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Demers D. M., Bass J. W., Vincent J. M., Person D. A., Noyes D. K., Staege C. M., Samlaska C. P., Lockwood N. H., Regnery R. L., Anderson B. E. Cat-scratch disease in Hawaii: etiology and seroepidemiology. J Pediatr. 1995 Jul;127(1):23–26. doi: 10.1016/s0022-3476(95)70251-2. [DOI] [PubMed] [Google Scholar]
  7. Greene C. E., McDermott M., Jameson P. H., Atkins C. L., Marks A. M. Bartonella henselae infection in cats: evaluation during primary infection, treatment, and rechallenge infection. J Clin Microbiol. 1996 Jul;34(7):1682–1685. doi: 10.1128/jcm.34.7.1682-1685.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hadfield T. L., Warren R., Kass M., Brun E., Levy C. Endocarditis caused by Rochalimaea henselae. Hum Pathol. 1993 Oct;24(10):1140–1141. doi: 10.1016/0046-8177(93)90196-n. [DOI] [PubMed] [Google Scholar]
  9. Hof H. Intracellular microorganisms: a particular problem for chemotherapy. Introduction. Infection. 1991;19 (Suppl 4):S193–S194. doi: 10.1007/BF01644031. [DOI] [PubMed] [Google Scholar]
  10. Holley H. P., Jr Successful treatment of cat-scratch disease with ciprofloxacin. JAMA. 1991 Mar 27;265(12):1563–1565. [PubMed] [Google Scholar]
  11. Koehler J. E., Glaser C. A., Tappero J. W. Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir. JAMA. 1994 Feb 16;271(7):531–535. doi: 10.1001/jama.271.7.531. [DOI] [PubMed] [Google Scholar]
  12. Kordick D. L., Breitschwerdt E. B. Intraerythrocytic presence of Bartonella henselae. J Clin Microbiol. 1995 Jun;33(6):1655–1656. doi: 10.1128/jcm.33.6.1655-1656.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kordick D. L., Breitschwerdt E. B. Relapsing bacteremia after blood transmission of Bartonella henselae to cats. Am J Vet Res. 1997 May;58(5):492–497. [PubMed] [Google Scholar]
  14. Kordick D. L., Hilyard E. J., Hadfield T. L., Wilson K. H., Steigerwalt A. G., Brenner D. J., Breitschwerdt E. B. Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease). J Clin Microbiol. 1997 Jul;35(7):1813–1818. doi: 10.1128/jcm.35.7.1813-1818.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kordick D. L., Swaminathan B., Greene C. E., Wilson K. H., Whitney A. M., O'Connor S., Hollis D. G., Matar G. M., Steigerwalt A. G., Malcolm G. B. Bartonella vinsonii subsp. berkhoffii subsp. nov., isolated from dogs; Bartonella vinsonii subsp. vinsonii; and emended description of Bartonella vinsonii. Int J Syst Bacteriol. 1996 Jul;46(3):704–709. doi: 10.1099/00207713-46-3-704. [DOI] [PubMed] [Google Scholar]
  16. Kordick D. L., Wilson K. H., Sexton D. J., Hadfield T. L., Berkhoff H. A., Breitschwerdt E. B. Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients. J Clin Microbiol. 1995 Dec;33(12):3245–3251. doi: 10.1128/jcm.33.12.3245-3251.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lee W. R., Chawla J. C., Reid R. Bacillary angiomatosis of the conjunctiva. Am J Ophthalmol. 1994 Aug 15;118(2):152–157. doi: 10.1016/s0002-9394(14)72894-6. [DOI] [PubMed] [Google Scholar]
  18. Margileth A. M. Antibiotic therapy for cat-scratch disease: clinical study of therapeutic outcome in 268 patients and a review of the literature. Pediatr Infect Dis J. 1992 Jun;11(6):474–478. [PubMed] [Google Scholar]
  19. Maurin M., Gasquet S., Ducco C., Raoult D. MICs of 28 antibiotic compounds for 14 Bartonella (formerly Rochalimaea) isolates. Antimicrob Agents Chemother. 1995 Nov;39(11):2387–2391. doi: 10.1128/aac.39.11.2387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Maurin M., Lepocher H., Mallet D., Raoult D. Antibiotic susceptibilities of Afipia felis in axenic medium and in cells. Antimicrob Agents Chemother. 1993 Jul;37(7):1410–1413. doi: 10.1128/aac.37.7.1410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Maurin M., Raoult D. Antimicrobial susceptibility of Rochalimaea quintana, Rochalimaea vinsonii, and the newly recognized Rochalimaea henselae. J Antimicrob Chemother. 1993 Oct;32(4):587–594. doi: 10.1093/jac/32.4.587. [DOI] [PubMed] [Google Scholar]
  22. Mui B. S., Mulligan M. E., George W. L. Response of HIV-associated disseminated cat scratch disease to treatment with doxycycline. Am J Med. 1990 Aug;89(2):229–231. doi: 10.1016/0002-9343(90)90303-u. [DOI] [PubMed] [Google Scholar]
  23. Musso D., Drancourt M., Raoult D. Lack of bactericidal effect of antibiotics except aminoglycosides on Bartonella (Rochalimaea) henselae. J Antimicrob Chemother. 1995 Jul;36(1):101–108. doi: 10.1093/jac/36.1.101. [DOI] [PubMed] [Google Scholar]
  24. Pocidalo J. J. Use of fluoroquinolones for intracellular pathogens. Rev Infect Dis. 1989 Jul-Aug;11 (Suppl 5):S979–S984. doi: 10.1093/clinids/11.supplement_5.s979. [DOI] [PubMed] [Google Scholar]
  25. Regnery R. L., Rooney J. A., Johnson A. M., Nesby S. L., Manzewitsch P., Beaver K., Olson J. G. Experimentally induced Bartonella henselae infections followed by challenge exposure and antimicrobial therapy in cats. Am J Vet Res. 1996 Dec;57(12):1714–1719. [PubMed] [Google Scholar]
  26. Riond J. L., Vaden S. L., Riviere J. E. Comparative pharmacokinetics of doxycycline in cats and dogs. J Vet Pharmacol Ther. 1990 Dec;13(4):415–424. doi: 10.1111/j.1365-2885.1990.tb00797.x. [DOI] [PubMed] [Google Scholar]
  27. Schwartzman W. A. Infections due to Rochalimaea: the expanding clinical spectrum. Clin Infect Dis. 1992 Dec;15(6):893–900. doi: 10.1093/clind/15.6.893. [DOI] [PubMed] [Google Scholar]
  28. Wilson K. H., Blitchington R. B., Greene R. C. Amplification of bacterial 16S ribosomal DNA with polymerase chain reaction. J Clin Microbiol. 1990 Sep;28(9):1942–1946. doi: 10.1128/jcm.28.9.1942-1946.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

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