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. 1997 Nov;41(11):2540–2543. doi: 10.1128/aac.41.11.2540

Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.

T Köhler 1, M Michea-Hamzehpour 1, P Plesiat 1, A L Kahr 1, J C Pechere 1
PMCID: PMC164158  PMID: 9371363

Abstract

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

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Selected References

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