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. 1997 Nov;41(11):2559–2561. doi: 10.1128/aac.41.11.2559

Penetration of teicoplanin into heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.

U K Frank 1, E Schmidt-Eisenlohr 1, D Mlangeni 1, M Schindler 1, A Hoh 1, F Beyersdorf 1, F D Daschner 1
PMCID: PMC164163  PMID: 9371368

Abstract

Penetration of teicoplanin into serum, heart valves, and subcutaneous and muscle tissues was determined in 22 patients undergoing open-heart surgery. Each patient received 12 mg of teicoplanin per kg of body weight as a 30-min intravenous infusion preoperatively. Within 10 h, serum concentrations of teicoplanin declined from 43.1 to 2.8 microg/ml. Teicoplanin concentrations in subcutaneous tissues reached their peak of 9.2 microg/g after 2 to 3 h and decreased slowly to 2.3 microg/g after 9 to 10 h. Concentrations in muscle decreased from 8.7 microg/g to nondetectable levels. Teicoplanin concentrations in cardiac valvular tissue reached their peak of 6.1 microg/g and decreased thereafter to 1.7 microg/g. Teicoplanin concentrations in heart valves were high enough to inhibit methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci, which are known to cause postoperative wound infections and infective endocarditis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bailey E. M., Rybak M. J., Kaatz G. W. Comparative effect of protein binding on the killing activities of teicoplanin and vancomycin. Antimicrob Agents Chemother. 1991 Jun;35(6):1089–1092. doi: 10.1128/aac.35.6.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Daschner F. D., Frank U., Kümmel A., Schmidt-Eisenlohr E., Schlosser V., Spillner H., Schuster B., Schindler M. Pharmacokinetics of vancomycin in serum and tissue of patients undergoing open-heart surgery. J Antimicrob Chemother. 1987 Mar;19(3):359–362. doi: 10.1093/jac/19.3.359. [DOI] [PubMed] [Google Scholar]
  4. Del Favero A., Patoia L., Rosina R., Buniva G., Danese A., Bernareggi A., Molini E., Cavenaghi L. Pharmacokinetics and tolerability of teicoplanin in healthy volunteers after single increasing doses. Antimicrob Agents Chemother. 1991 Dec;35(12):2551–2557. doi: 10.1128/aac.35.12.2551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Frank U., Kappstein I., Schmidt-Eisenlohr E., Schlosser V., Spillner G., Schindler M., Daschner F. D. Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery. Antimicrob Agents Chemother. 1987 May;31(5):813–814. doi: 10.1128/aac.31.5.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Frank U., Schmidt-Eisenlohr E., Schlosser V., Spillner G., Schindler M., Daschner F. D. Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery. Antimicrob Agents Chemother. 1988 Jun;32(6):930–931. doi: 10.1128/aac.32.6.930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goldstein F. W., Coutrot A., Sieffer A., Acar J. F. Percentages and distributions of teicoplanin- and vancomycin-resistant strains among coagulase-negative staphylococci. Antimicrob Agents Chemother. 1990 May;34(5):899–900. doi: 10.1128/aac.34.5.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gorzynski E. A., Amsterdam D., Beam T. R., Jr, Rotstein C. Comparative in vitro activities of teicoplanin, vancomycin, oxacillin, and other antimicrobial agents against bacteremic isolates of gram-positive cocci. Antimicrob Agents Chemother. 1989 Nov;33(11):2019–2022. doi: 10.1128/aac.33.11.2019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Martin C., Bourget P., Alaya M., Sertin A., Atlani C., Ennabli K., Said R. Teicoplanin in cardiac surgery: intraoperative pharmacokinetics and concentrations in cardiac and mediastinal tissues. Antimicrob Agents Chemother. 1997 May;41(5):1150–1155. doi: 10.1128/aac.41.5.1150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rowland M. Clinical pharmacokinetics of teicoplanin. Clin Pharmacokinet. 1990 Mar;18(3):184–209. doi: 10.2165/00003088-199018030-00002. [DOI] [PubMed] [Google Scholar]
  11. Sharpe A. N., Jackson A. K. Stomaching: a new concept in bacteriological sample preparation. Appl Microbiol. 1972 Aug;24(2):175–178. doi: 10.1128/am.24.2.175-178.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shea K. W., Cunha B. A. Teicoplanin. Med Clin North Am. 1995 Jul;79(4):833–844. doi: 10.1016/s0025-7125(16)30042-6. [DOI] [PubMed] [Google Scholar]
  13. Smithers J. A., Kulmala H. K., Thompson G. A., Antony K. K., Lewis E. W., Ruberg S. J., Kenny M. T., Dulworth J. K., Brackman M. A. Pharmacokinetics of teicoplanin upon multiple-dose intravenous administration of 3, 12, and 30 milligrams per kilogram of body weight to healthy male volunteers. Antimicrob Agents Chemother. 1992 Jan;36(1):115–120. doi: 10.1128/aac.36.1.115. [DOI] [PMC free article] [PubMed] [Google Scholar]

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