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. 1997 Nov;41(11):2566–2569. doi: 10.1128/aac.41.11.2566

Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.

J R Lokensgard 1, G Gekker 1, S Hu 1, A F Arthur 1, C C Chao 1, P K Peterson 1
PMCID: PMC164165  PMID: 9371370

Abstract

Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.

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Selected References

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