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. 1997 Dec;41(12):2776–2780. doi: 10.1128/aac.41.12.2776

Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens.

B C Herold 1, A Siston 1, J Bremer 1, R Kirkpatrick 1, G Wilbanks 1, P Fugedi 1, C Peto 1, M Cooper 1
PMCID: PMC164209  PMID: 9420059

Abstract

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

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Selected References

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