Abstract
Demerol and methadone have advantages over morphine. Demerol requires a higher dosage than methadone, but produces less respiratory depression. Therefore, it can be used more freely in cases where respiratory depression is contraindicated. Demerol does not depress the cough reflex, and methadone is preferred for this purpose. Both drugs have a sufficient tendency to produce addiction that the usual narcotic restrictions should be observed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hori C. G., Gold S. Demerol in Surgery and Obstetrics. Can Med Assoc J. 1944 Dec;51(6):509–517. [PMC free article] [PubMed] [Google Scholar]
- Scott C. C., Robbins E. B., Chen K. K. Comparison of Some New Analgesic Compounds. Science. 1946 Dec 20;104(2712):587–588. doi: 10.1126/science.104.2712.587. [DOI] [PubMed] [Google Scholar]