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. 1987 May;77(5):554–559. doi: 10.2105/ajph.77.5.554

Toxocara canis infection of children: epidemiologic and neuropsychologic findings.

M Marmor, L Glickman, F Shofer, L A Faich, C Rosenberg, B Cornblatt, S Friedman
PMCID: PMC1647039  PMID: 3565646

Abstract

Sera from 4,652 children whose blood was submitted to the New York City Department of Health for lead analysis were tested for antibodies to Toxocara canis using an enzyme-linked immunosorbent assay (ELISA). Standardized to the age distribution of the study population, T. canis seropositivity (inverse titers greater than or equal to 16) was 5.7 per cent in males and 5.1 per cent in females. T. canis antibody titers and lead exposures as measured by Centers for Disease Control lead classes were positively correlated. Children who were seropositive to T. canis (cases) were compared to seronegatives (controls) matched on age (+/- 6 months), sex, time-of-screening (+/- 3 months) and CDC lead class. Logistic regression analysis of 155 case-control pairs demonstrated elevated relative risks (RRs) for geophagia (RR = 3.14; 95% CI = 1.75, 5.64) and having had a litter of puppies in the home (RR = 5.22; 95% CI = 1.63, 16.71). Compared to controls, cases had increased eosinophil counts, serum immunoglobulin E concentrations, and anti-hemagglutinin-A titers. Small deficits in cases compared to controls were found in performance on several neuropsychological tests after adjustment for potential confounders including case-control differences in race, socioeconomic status, and current blood lead concentrations. The study thus confirmed that T. canis infection is common in urban children and suggested that infection may be associated with adverse neuropsychological effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aur R. J., Pratt C. B., Johnson W. W. Thiabendazole in visceral larva migrans. Am J Dis Child. 1971 Mar;121(3):226–229. doi: 10.1001/archpedi.1971.02100140092008. [DOI] [PubMed] [Google Scholar]
  2. Berger O. G., Hornstein M. D. Eosinophilia and pica: lead or parasites? Lancet. 1980 Mar 8;1(8167):553–553. doi: 10.1016/s0140-6736(80)92818-4. [DOI] [PubMed] [Google Scholar]
  3. Bialer I., Doll L., Winsberg B. G. A modified Lincoln-Oseretsky Motor Development Scale: provisional standardization. Percept Mot Skills. 1974 Apr;38(2):599–614. doi: 10.2466/pms.1974.38.2.599. [DOI] [PubMed] [Google Scholar]
  4. Brunello F., Genchi C., Falagiani P. Detection of larva-specific IgE in human toxocariasis. Trans R Soc Trop Med Hyg. 1983;77(2):279–280. doi: 10.1016/0035-9203(83)90096-2. [DOI] [PubMed] [Google Scholar]
  5. Cornblatt B. A., Erlenmeyer-Kimling L. Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. J Abnorm Psychol. 1985 Nov;94(4):470–486. doi: 10.1037//0021-843x.94.4.470. [DOI] [PubMed] [Google Scholar]
  6. Cypess R. H., Karol M. H., Zidian J. L., Glickman L. T., Gitlin D. Larva-specific antibodies in patients with visceral larva migrans. J Infect Dis. 1977 Apr;135(4):633–640. doi: 10.1093/infdis/135.4.633. [DOI] [PubMed] [Google Scholar]
  7. Dolinsky Z. S., Burright R. G., Donovick P. J., Glickman L. T., Babish J., Summers B., Cypess R. H. Behavioral effects of lead and Toxocara canis in mice. Science. 1981 Sep 4;213(4512):1142–1144. doi: 10.1126/science.7268424. [DOI] [PubMed] [Google Scholar]
  8. Dolinsky Z. S., Hardy C. A., Burright R. G., Donovick P. J. The progression of behavioral and pathological effects of the parasite Toxocara canis in the mouse. Physiol Behav. 1985 Jul;35(1):33–42. doi: 10.1016/0031-9384(85)90168-4. [DOI] [PubMed] [Google Scholar]
  9. Düwel D. The prevalence of Toxocara eggs in the sand in children's playgrounds in Frankfurt/M. Ann Trop Med Parasitol. 1984 Dec;78(6):633–636. [PubMed] [Google Scholar]
  10. Glickman L. T., Cypess R. H., Crumrine P. K., Gitlin D. A. Toxocara infection and epilepsy in children. J Pediatr. 1979 Jan;94(1):75–78. doi: 10.1016/s0022-3476(79)80359-5. [DOI] [PubMed] [Google Scholar]
  11. Glickman L. T., Schantz P. M., Cypess R. H. Epidemiological characteristics and clinical findings in patients with serologically proven toxocariasis. Trans R Soc Trop Med Hyg. 1979;73(3):254–258. doi: 10.1016/0035-9203(79)90077-4. [DOI] [PubMed] [Google Scholar]
  12. Glickman L. T., Schantz P. M. Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol Rev. 1981;3:230–250. doi: 10.1093/oxfordjournals.epirev.a036235. [DOI] [PubMed] [Google Scholar]
  13. Glickman L., Schantz P., Dombroske R., Cypess R. Evaluation of serodiagnostic tests for visceral larva migrans. Am J Trop Med Hyg. 1978 May;27(3):492–498. doi: 10.4269/ajtmh.1978.27.492. [DOI] [PubMed] [Google Scholar]
  14. Herrmann N., Glickman L. T., Schantz P. M., Weston M. G., Domanski L. M. Seroprevalence of zoonotic toxocariasis in the United States: 1971-1973. Am J Epidemiol. 1985 Nov;122(5):890–896. doi: 10.1093/oxfordjournals.aje.a114172. [DOI] [PubMed] [Google Scholar]
  15. Hill I. R., Denham D. A., Scholtz C. L. Toxocara canis larvae in the brain of a British child. Trans R Soc Trop Med Hyg. 1985;79(3):351–354. doi: 10.1016/0035-9203(85)90378-5. [DOI] [PubMed] [Google Scholar]
  16. Koppitz E. M. Visual Aural Digit Span Test performance of boys with emotional and learning problems. J Clin Psychol. 1973 Oct;29(4):463–466. doi: 10.1002/1097-4679(197310)29:4<463::aid-jclp2270290418>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  17. MOORE M. T. Human Toxocara canis encephalitis with lead encephalopathy. J Neuropathol Exp Neurol. 1962 Apr;21:201–218. doi: 10.1097/00005072-196204000-00004. [DOI] [PubMed] [Google Scholar]
  18. Mikhael N. Z., Montpetit V. J., Orizaga M., Rowsell H. C., Richard M. T. Toxocara canis infestation with encephalitis. Can J Neurol Sci. 1974 May;1(2):114–120. doi: 10.1017/s0317167100019661. [DOI] [PubMed] [Google Scholar]
  19. Mok C. H. Visceral larva migrans. A discussion based on review of the literature. Clin Pediatr (Phila) 1968 Sep;7(9):565–573. doi: 10.1177/000992286800700912. [DOI] [PubMed] [Google Scholar]
  20. Olson L. J., Rose J. E. Effect of Toxocara canis infection on the ability of white rats to solve maze problems. Exp Parasitol. 1966 Aug;19(1):77–84. doi: 10.1016/0014-4894(66)90055-5. [DOI] [PubMed] [Google Scholar]
  21. SLOAN W. The Lincoln-Oseretsky motor development scale. Genet Psychol Monogr. 1955 May;51(2):183–252. [PubMed] [Google Scholar]
  22. SPRENT J. F. Observations on the development of Toxocara canis (Werner, 1782) in the dog. Parasitology. 1958 May;48(1-2):184–209. doi: 10.1017/s0031182000021168. [DOI] [PubMed] [Google Scholar]
  23. Sackett D. L. Bias in analytic research. J Chronic Dis. 1979;32(1-2):51–63. doi: 10.1016/0021-9681(79)90012-2. [DOI] [PubMed] [Google Scholar]
  24. Schantz P. M., Weis P. E., Pollard Z. F., White M. C. Risk factors for toxocaral ocular larva migrans: a case-control study. Am J Public Health. 1980 Dec;70(12):1269–1272. doi: 10.2105/ajph.70.12.1269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Worley G., Green J. A., Frothingham T. E., Sturner R. A., Walls K. W., Pakalnis V. A., Ellis G. S., Jr Toxocara canis infection: clinical and epidemiological associations with seropositivity in kindergarten children. J Infect Dis. 1984 Apr;149(4):591–597. doi: 10.1093/infdis/149.4.591. [DOI] [PubMed] [Google Scholar]
  26. Zinkham W. H. Visceral larva migrans. A review and reassessment indicating two forms of clinical expression: visceral and ocular. Am J Dis Child. 1978 Jun;132(6):627–633. doi: 10.1001/archpedi.1978.02120310091020. [DOI] [PubMed] [Google Scholar]

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