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. 1987 Oct;77(10):1294–1297. doi: 10.2105/ajph.77.10.1294

Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects on growth, morbidity, and duration of lactation.

W J Rogan, B C Gladen, J D McKinney, N Carreras, P Hardy, J Thullen, J Tingelstad, M Tully
PMCID: PMC1647130  PMID: 3115123

Abstract

We followed 858 children from birth to one year of age to determine whether the presence of polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in breast milk affected their growth or health. Neither chemical showed an adverse effect on weight or frequency of physician visits for various illnesses, although differences were seen between breast-fed and bottle-fed children, with bottle-fed children being heavier and having more frequent gastroenteritis and otitis media. Children of mothers with higher levels of DDE were breast-fed for markedly shorter times, but adjustments for possible confounders and biases did not change the findings. In absence of any apparent effect on the health of the children, we speculate that DDE may be interfering with the mother's ability to lactate, possibly because of its estrogenic properties.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen A. N., Lund-Andersen C., Larsen J. F., Christensen N. J., Legros J. J., Louis F., Angelo H., Molin J. Suppressed prolactin but normal neurophysin levels in cigarette smoking breast-feeding women. Clin Endocrinol (Oxf) 1982 Oct;17(4):363–368. doi: 10.1111/j.1365-2265.1982.tb01601.x. [DOI] [PubMed] [Google Scholar]
  2. Dyment P. G., Hebertson L. M., Gomes E. D., Wiseman J. S., Hornabrook R. W. Absence of polychlorinated biphenyls in human milk and serum from Texas and human milk from New Guinea. Bull Environ Contam Toxicol. 1971 Nov-Dec;6(6):532–534. doi: 10.1007/BF01796861. [DOI] [PubMed] [Google Scholar]
  3. Feinstein J. M., Berkelhamer J. E., Gruszka M. E., Wong C. A., Carey A. E. Factors related to early termination of breast-feeding in an urban population. Pediatrics. 1986 Aug;78(2):210–215. [PubMed] [Google Scholar]
  4. Gellert R. J. Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environ Res. 1978 Jul;16(1-3):123–130. doi: 10.1016/0013-9351(78)90149-4. [DOI] [PubMed] [Google Scholar]
  5. Habicht J. P., DaVanzo J., Butz W. P. Does breastfeeding really save lives, or are apparent benefits due to biases? Am J Epidemiol. 1986 Feb;123(2):279–290. doi: 10.1093/oxfordjournals.aje.a114236. [DOI] [PubMed] [Google Scholar]
  6. Jensen A. A. Chemical contaminants in human milk. Residue Rev. 1983;89:1–128. doi: 10.1007/978-1-4612-5601-4_1. [DOI] [PubMed] [Google Scholar]
  7. LAUG E. P., KUNZE F. M., PRICKETT C. S. Occurrence of DDT in human fat and milk. AMA Arch Ind Hyg Occup Med. 1951 Mar;3(3):245–246. [PubMed] [Google Scholar]
  8. McKinney J. D., Moore L., Prokopetz A., Walters D. B. Validated extraction and cleanup procedures for polychlorinated biphenyls and DDE in human body fluids and infant formula. J Assoc Off Anal Chem. 1984 Jan-Feb;67(1):122–129. [PubMed] [Google Scholar]
  9. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tingelstad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 Feb;76(2):172–177. doi: 10.2105/ajph.76.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986 Aug;109(2):335–341. doi: 10.1016/s0022-3476(86)80397-3. [DOI] [PubMed] [Google Scholar]
  11. Tankeyoon M., Dusitsin N., Chalapati S., Koetsawang S., Saibiang S., Sas M., Gellen J. J., Ayeni O., Gray R., Pinol A. Effects of hormonal contraceptives on milk volume and infant growth. WHO Special Programme of Research, Development and Research Training in Human Reproduction Task force on oral contraceptives. Contraception. 1984 Dec;30(6):505–522. doi: 10.1016/0010-7824(84)90001-5. [DOI] [PubMed] [Google Scholar]
  12. Weil W. B., Spencer M., Benjamin D., Seagull E. The effect of polybrominated biphenyl on infants and young children. J Pediatr. 1981 Jan;98(1):47–51. doi: 10.1016/s0022-3476(81)80531-8. [DOI] [PubMed] [Google Scholar]
  13. Wickizer T. M., Brilliant L. B. Testing for polychlorinated biphenyls in human milk. Pediatrics. 1981 Sep;68(3):411–415. [PubMed] [Google Scholar]
  14. Yeung D. L., Pennell M. D., Leung M., Hall J. Breastfeeding: prevalence and influencing factors. Can J Public Health. 1981 Sep-Oct;72(5):323–330. [PubMed] [Google Scholar]

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