Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1970 Dec;45(244):766–768. doi: 10.1136/adc.45.244.766

Evaluation of the Effects of Isoprenaline and Salbutamol Aerosols on Airways Obstruction and Pulse Rates of Children with Asthma*

G Hambleton, E A Shinebourne
PMCID: PMC1647441  PMID: 4923642

Abstract

Investigation of FEV1·0 and pulse rates in 10 asthmatic children who were given inhalations of isoprenaline, salbutamol, and placebo separately showed that both drugs had a similar effect on airways obstruction. Salbutamol has a longer duration of action. Neither drug caused a tachycardia at the dosage used.

Full text

PDF
766

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cullum V. A., Farmer J. B., Jack D., Levy G. P. Salbutamol: a new, selective beta-adrenoceptive receptor stimulant. Br J Pharmacol. 1969 Jan;35(1):141–151. doi: 10.1111/j.1476-5381.1969.tb07975.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hartley D., Jack D., Lunts L. H., Ritchie A. C. New class of selective stimulants of beta-adrenergic receptors. Nature. 1968 Aug 24;219(5156):861–862. doi: 10.1038/219861a0. [DOI] [PubMed] [Google Scholar]
  4. Kelman G. R., Palmer K. N., Cross M. R. Cardiovascular effects of AH.3365 (salbutamol). Nature. 1969 Mar 29;221(5187):1251–1251. doi: 10.1038/2211251a0. [DOI] [PubMed] [Google Scholar]
  5. Kennedy M. C., Simpson W. T. Human pharmacological and clinical studies on salbutamol: a specific beta-adrenergic bronchodilator. Br J Dis Chest. 1969 Jul;63(3):165–174. doi: 10.1016/s0007-0971(69)80014-8. [DOI] [PubMed] [Google Scholar]
  6. Palmer K. N., Diament M. L. Effect of salbutamol on spirometry and blood-gas tensions in bronchial asthma. Br Med J. 1969 Jan 4;1(5635):31–32. doi: 10.1136/bmj.1.5635.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Riding W. D., Chatterjee S. S., Dinda P. Clinical trial of a new B-adrenergic stimulant in asthma. Br J Clin Pract. 1969 May;23(5):217–219. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES