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. 1970 Aug;45(242):544–546. doi: 10.1136/adc.45.242.544

Comparison of Serum Growth Hormone Levels after Bovril and Insulin Stimulation

D B Grant, Doreen Jackson, S Raiti, Barbara E Clayton
PMCID: PMC1647626  PMID: 5506941

Abstract

Serum growth hormone (HGH) levels were estimated in 60 children during Bovril and intravenous insulin tests. The results of the two tests correlated well. 37 subjects had HGH levels over 10 μIU/ml. during both tests, and 18 subjects failed to respond to either test. 4 subjects showed minor discrepancies between the results of the two tests, and one child with the emotional deprivation syndrome had a good response to insulin but no significant rise in serum HGH during her first Bovril test. It was concluded that the two tests were of comparable value in the assessment of children with suspected growth hormone deficiency, and that the Bovril test had the advantages of being safe and avoiding intravenous administration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buckler J. M. The effect of age, sex and exercise on the secretion of growth hormone. Clin Sci. 1969 Dec;37(3):765–774. [PubMed] [Google Scholar]
  2. FITSCHEN W. A QUANTITATIVE STUDY OF ANTIGEN--ANTIBODY COMBINATION DURING DISK ELECTROPHORESIS IN ACRYLAMIDE GEL USING IODINE-131 LABELLED HUMAN GROWTH HORMONE. Immunology. 1964 May;7:307–315. [PMC free article] [PubMed] [Google Scholar]
  3. Frohman L. A., Aceto T., Jr, MacGillivray M. H. Studies of growth hormone secretion in children: normal, hypopituitary and constitutionally delayed. J Clin Endocrinol Metab. 1967 Oct;27(10):1409–1417. doi: 10.1210/jcem-27-10-1409. [DOI] [PubMed] [Google Scholar]
  4. Gagliardino J. J., Bailey J. D., Martin J. M. Effect of vasopressin on serum-levels of human growth hormone. Lancet. 1967 Jun 24;1(7504):1357–1358. doi: 10.1016/s0140-6736(67)91764-3. [DOI] [PubMed] [Google Scholar]
  5. HUNTER W. M., GREENWOOD F. C. STUDIES ON THE SECRETION OF HUMAN-PITUITARY-GROWTH HORMONE. Br Med J. 1964 Mar 28;1(5386):804–807. doi: 10.1136/bmj.1.5386.804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hunter W. M., Rigal W. M. The diurnal pattern of plasma growth hormone concentration in children and adolescents. J Endocrinol. 1966 Feb;34(2):147–153. doi: 10.1677/joe.0.0340147. [DOI] [PubMed] [Google Scholar]
  7. Jackson D., Grant D. B., Clayton B. E. A simple oral test of growth-hormone secretion in children. Lancet. 1968 Aug 17;2(7564):373–375. doi: 10.1016/s0140-6736(68)90592-8. [DOI] [PubMed] [Google Scholar]
  8. KNOPF R. F., CONN J. W., FAJANS S. S., FLOYD J. C., GUNTSCHE E. M., RULL J. A. PLASMA GROWTH HORMONE RESPONSE TO INTRAVENOUS ADMINISTRATION OF AMINO ACIDS. J Clin Endocrinol Metab. 1965 Aug;25:1140–1144. doi: 10.1210/jcem-25-8-1140. [DOI] [PubMed] [Google Scholar]
  9. Mitchell M. L., Byrne M. J., Silver J. Growth-hormone release by glucagon. Lancet. 1969 Feb 8;1(7589):289–290. doi: 10.1016/s0140-6736(69)91041-1. [DOI] [PubMed] [Google Scholar]
  10. Parker M. L., Hammond J. M., Daughaday W. H. The arginine provocative test: an aid in the diagnosis of hyposomatotropism. J Clin Endocrinol Metab. 1967 Aug;27(8):1129–1136. doi: 10.1210/jcem-27-8-1129. [DOI] [PubMed] [Google Scholar]
  11. ROTH J., GLICK S. M., YALOW R. S., BERSONSA Hypoglycemia: a potent stimulus to secretion of growth hormone. Science. 1963 May 31;140(3570):987–988. doi: 10.1126/science.140.3570.987. [DOI] [PubMed] [Google Scholar]
  12. Raiti S., Davis W. T., Blizzard R. M. A comparison of the effects of insulin hypoglycaemia and arginine infusion on release of human growth hormone. Lancet. 1967 Dec 2;2(7527):1182–1183. doi: 10.1016/s0140-6736(67)91896-x. [DOI] [PubMed] [Google Scholar]
  13. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child. 1966 Oct;41(219):454–471. doi: 10.1136/adc.41.219.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969 Mar;22(2):158–161. doi: 10.1136/jcp.22.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wolfsdorf J., Farquhar J. W., Rigal W. M. Screening tests for growth-hormone deficiency in dwarfism. Lancet. 1967 Dec 16;2(7529):1271–1273. doi: 10.1016/s0140-6736(67)90389-3. [DOI] [PubMed] [Google Scholar]
  16. Youlton R., Kaplan S. L., Grumbach M. M. Growth and growth hormone. IV. Limitations of the growth hormone response to insulin and arginine and of the immunoreactive insulin response to arginine in the assessment of growth hormone deficiency in children. Pediatrics. 1969 Jun;43(6):989–1004. [PubMed] [Google Scholar]

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