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. 1970 Aug;45(242):478–484. doi: 10.1136/adc.45.242.478

Output of Luteinizing Hormone in the Urine of Normal Children and Those with Advanced Sexual Development

J M H Buckler, Barbara E Clayton
PMCID: PMC1647652  PMID: 5506934

Abstract

Estimations by radioimmunoassay of the 24-hour excretion of LH in normal children (152 boys and 104 girls) have shown high values in the first six months of life in boys, and possibly girls, and then low levels until the age of about 6 years. There is then a gradual rise in LH excretion in both sexes which continues for the 3-4 years which precede the onset of puberty, at which age a more marked increase occurs. 13 cases of true precocious puberty were all found to be associated with increased urinary excretion of LH, a feature that was seldom shown with other forms of advanced sexual development. Measurement of urinary LH excretion provides a useful tool in the differentiation of such conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN P. S. Human urinary gonadotrophins. I. In relation to puberty. J Endocrinol. 1958 Nov;17(4):329–336. doi: 10.1677/joe.0.0170329. [DOI] [PubMed] [Google Scholar]
  2. Bagshawe K. D., Wilde C. E., Orr A. H. Radioimmunoassay for human chorionic gonadotrophin and luteinising hormone. Lancet. 1966 May 21;1(7447):1118–1121. doi: 10.1016/s0140-6736(66)91136-6. [DOI] [PubMed] [Google Scholar]
  3. Buckler J. M., Clayton B. E. Studies on the specificity of the radioimmunoassay of luteinising hormone. Acta Endocrinol (Copenh) 1970 Mar;63(3):545–561. doi: 10.1530/acta.0.0630545. [DOI] [PubMed] [Google Scholar]
  4. Johanson A. J., Guyda H., Light C., Migeon C. J., Blizzard R. M. Serum luteinizing hormone by radioimmunoassay in normal children. J Pediatr. 1969 Mar;74(3):416–424. doi: 10.1016/s0022-3476(69)80200-3. [DOI] [PubMed] [Google Scholar]
  5. Kenny F. M., Midgley A. R., Jr, Jaffe R. B., Garces L. Y., Vazquez A., Taylor F. H. Radioimmunoassayable serum LH and FSH in girls with sexual precocity, premature thelarche and adrenarche. J Clin Endocrinol Metab. 1969 Sep;29(9):1272–1275. doi: 10.1210/jcem-29-9-1272. [DOI] [PubMed] [Google Scholar]
  6. Kulin H. E., Rifkind A. B., Ross G. T. Human luteinizing hormone (LH) activity in processed and unprocessed urine measured by radioimmunoassay and bioassay. J Clin Endocrinol Metab. 1968 Apr;28(4):543–546. doi: 10.1210/jcem-28-4-543. [DOI] [PubMed] [Google Scholar]
  7. Kulin H. E., Rifkind A. B., Ross G. T., Odell W. D. Total gonadotropin activity in the urine of prepubertal children. J Clin Endocrinol Metab. 1967 Aug;27(8):1123–1128. doi: 10.1210/jcem-27-8-1123. [DOI] [PubMed] [Google Scholar]
  8. Raiti S., Blizzard R. M. Measurement of immunologically reactive follicle stimulating hormone in human urine by radioimmunoassay. J Clin Endocrinol Metab. 1968 Dec;28(12):1719–1723. doi: 10.1210/jcem-28-12-1719. [DOI] [PubMed] [Google Scholar]
  9. Rifkind A. B., Kulin H. E., Ross G. T. Follicle-stimulating hormone (FSH) and luteninizing hormone (LH) in the urine of prepubertal children. J Clin Invest. 1967 Dec;46(12):1925–1931. doi: 10.1172/JCI105682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Schalch D. S., Parlow A. F., Boon R. C., Reichlin S. Measurement of human luteinizing hormone in plasma by radioimmunoassay. J Clin Invest. 1968 Mar;47(3):665–678. doi: 10.1172/JCI105762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Stevens V. C. Comparison of FSH and LH patterns in plasma, urine and urinary extracts during the menstrual cycle. J Clin Endocrinol Metab. 1969 Jul;29(7):904–910. doi: 10.1210/jcem-29-7-904. [DOI] [PubMed] [Google Scholar]

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