Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1971 Oct;46(249):705–708. doi: 10.1136/adc.46.249.705

Coeliac disease

Reappraisal of clinical diagnosis

D M Cook, N Evans, Anne Lloyd, J S Stewart
PMCID: PMC1647845  PMID: 5118061

Abstract

Twelve children previously diagnosed as having coeliac disease on criteria now regarded as incomplete have been reinvestigated. Six were found to have an intestinal mucosal lesion characteristic of coeliac disease. All but one had been asymptomatic on a normal diet for more than 18 months. Response to diet fails to distinguish between coeliacs and non-coeliacs. Establishing the diagnosis of coeliac disease by intestinal biopsy is essential, since even apparently symptomless individuals are at considerable risk.

Full text

PDF
705

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CROSBY W. H., KUGLER H. W. Intraluminal biopsy of the small intestine; the intestinal biopsy capsule. Am J Dig Dis. 1957 May;2(5):236–241. doi: 10.1007/BF02231100. [DOI] [PubMed] [Google Scholar]
  2. Cook D. M., Evans N., Lloyd A., Stewart J. S. Normal serum and red-cell folate levels in a child with coeliac disease. Lancet. 1970 Mar 14;1(7646):571–572. doi: 10.1016/s0140-6736(70)90813-5. [DOI] [PubMed] [Google Scholar]
  3. Evans N., Farrow L. J., Harding A., Stewart J. S. New techniques for speeding small intestinal biopsy. Gut. 1970 Jan;11(1):88–89. doi: 10.1136/gut.11.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GOUGH K. R., READ A. E., NAISH J. M. Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut. 1962 Sep;3:232–239. doi: 10.1136/gut.3.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Giles C. An account of 335 cases of megaloblastic anaemia of pregnancy and the puerperium. J Clin Pathol. 1966 Jan;19(1):1–11. doi: 10.1136/jcp.19.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HIBBARD B. M., HIBBARD E. D. AETIOLOGICAL FACTORS IN ABRUPTIO PLACENTAE. Br Med J. 1963 Dec 7;2(5370):1430–1436. doi: 10.1136/bmj.2.5370.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOLMES R., HOURIHANE D. O., BOOTH C. C. Dissecting-microscope appearances of jejunal biopsy specimens from patients with "idiopathic steatorrhoea". Lancet. 1961 Jan 14;1(7168):81–83. doi: 10.1016/s0140-6736(61)92123-7. [DOI] [PubMed] [Google Scholar]
  8. Hamilton J. R., Lynch M. J., Reilly B. J. Active coeliac disease in childhood. Clinical and laboratory findings of forty-two cases. Q J Med. 1969 Apr;38(150):135–158. [PubMed] [Google Scholar]
  9. Harris O. D., Cooke W. T., Thompson H., Waterhouse J. A. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. doi: 10.1016/0002-9343(67)90071-x. [DOI] [PubMed] [Google Scholar]
  10. Haworth E. M., Hodson C. J., Joyce C. R., Pringle E. M., Solimano G., Young W. F. Radiological measurement of smallbowel calibre in normal subjects according to age. Clin Radiol. 1967 Oct;18(4):417–421. doi: 10.1016/s0009-9260(67)80051-5. [DOI] [PubMed] [Google Scholar]
  11. Haworth E. M., Hodson C. J., Pringle E. M., Young W. F. The value of radiological investigations of the alimentary tract in children with the coeliac syndrome. Clin Radiol. 1968 Jan;19(1):65–76. doi: 10.1016/s0009-9260(68)80038-8. [DOI] [PubMed] [Google Scholar]
  12. Hoffbrand A. V., Newcombe F. A., Mollin D. L. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol. 1966 Jan;19(1):17–28. doi: 10.1136/jcp.19.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kilpatrick Z. M., Katz J. Occult celiac disease as a cause of iron deficiency anemia. JAMA. 1969 May 12;208(6):999–1001. [PubMed] [Google Scholar]
  14. MARTIN R. H., HARPER T. A., KELSO W. SERUM-FOLIC-ACID IN RECURRENT ABORTIONS. Lancet. 1965 Mar 27;1(7387):670–672. doi: 10.1016/s0140-6736(65)91826-x. [DOI] [PubMed] [Google Scholar]
  15. McNeish A. S. Diagnosis of coeliac disease in retrospect. Arch Dis Child. 1968 Jun;43(229):362–364. doi: 10.1136/adc.43.229.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McNeish A. S., Willoughby M. L. Whole-blood folate as a screening test for coeliac disease in childhood. Lancet. 1969 Mar 1;1(7592):442–443. doi: 10.1016/s0140-6736(69)91481-0. [DOI] [PubMed] [Google Scholar]
  17. Morris J. S., Adjukiewicz A. B., Read A. E. Coeliac infertility: an indication for dietary gluten restriction? Lancet. 1970 Jan 31;1(7640):213–214. doi: 10.1016/s0140-6736(70)90572-6. [DOI] [PubMed] [Google Scholar]
  18. Mortimer P. E., Stewart J. S., Norman A. P., Booth C. C. Follow-up study of coeliac disease. Br Med J. 1968 Jul 6;3(5609):7–9. doi: 10.1136/bmj.3.5609.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sheldon W. Prognosis in early adult life of coeliac children treated with a gluten-free diet. Br Med J. 1969 May 17;2(5654):401–404. doi: 10.1136/bmj.2.5654.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stewart J. S. Adult coeliac disease. Postgrad Med J. 1968 Aug;44(514):632–641. doi: 10.1136/pgmj.44.514.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stewart J. S., Pollock D. J., Hoffbrand A. V., Mollin D. L., Booth C. C. A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Q J Med. 1967 Jul;36(143):425–444. [PubMed] [Google Scholar]
  22. WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Whitfield C. R., Love A. H. Intestinal malabsorption in megaloblastic pregnancy anaemia. J Obstet Gynaecol Br Commonw. 1968 Aug;75(8):844–848. doi: 10.1111/j.1471-0528.1968.tb01603.x. [DOI] [PubMed] [Google Scholar]
  24. Wright J. T., Richardson P. C. Squamous carcinoma of the thoracic oesophagus in malabsorption syndrome. Br Med J. 1967 Mar 4;1(5539):540–542. doi: 10.1136/bmj.1.5539.540. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES