Abstract
Intestinal dipeptide hydrolase enzymes cleave dipeptides into amino acids. In 8 undernourished children with diarrhoea, mean intestinal mucosal glyclyl-proline hydrolase activity was reduced 40%, valyl-proline hydrolase activity 38%, and alkaline phosphatase activity 54%, as compared with 4 controls. The use of hydrolysed proteins or simple amino acid mixtures in the initial treatment of undernourished children is suggested.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOWIE M. D., BRINKMAN G. L., HANSEN J. D. ACQUIRED DISACCHARIDE INTOLERANCE IN MALNUTRITION. J Pediatr. 1965 Jun;66:1083–1091. doi: 10.1016/s0022-3476(65)80095-6. [DOI] [PubMed] [Google Scholar]
- Balmer S., Howells G., Wharton B. The acute encephalopathy of kwashiorkor. Dev Med Child Neurol. 1968 Dec;10(6):766–771. doi: 10.1111/j.1469-8749.1968.tb02975.x. [DOI] [PubMed] [Google Scholar]
- Berg N. O., Dahlqvist A., Lindberg T., Nordén A. Intestinal dipeptidases and disaccharidases in celiac disease in adults. Gastroenterology. 1970 Oct;59(4):575–582. [PubMed] [Google Scholar]
- Bowie M. D., Barbezat G. O., Hansen J. D. Carbohydrate absorption in malnourished children. Am J Clin Nutr. 1967 Feb;20(2):89–97. doi: 10.1093/ajcn/20.2.89. [DOI] [PubMed] [Google Scholar]
- CAREY J. B., Jr A SIMPLIFIED GASTROINTESTINAL BIOPSY CAPSULE. Gastroenterology. 1964 May;46:550–557. [PubMed] [Google Scholar]
- DE OLIVEIRA J. E., ROLANDO E. FAT ABSORPTION STUDIES IN MALNOURISHED CHILDREN. Am J Clin Nutr. 1964 Nov;15:287–292. doi: 10.1093/ajcn/15.5.287. [DOI] [PubMed] [Google Scholar]
- De Luca L., Little E. P., Wolf G. Vitamin A and protein synthesis by rat intestinal mucosa. J Biol Chem. 1969 Feb 25;244(4):701–708. [PubMed] [Google Scholar]
- Ghai O. P., Sandhu R. K. Study of physical growth of Indian children in Delhi. Indian J Pediatr. 1968 Feb;35(241):91–108. doi: 10.1007/BF02790612. [DOI] [PubMed] [Google Scholar]
- Guha D. K., Walia B. N., Tandon B. N., Deo M. G., Ghai O. P. Small bowel changes in iron-deficiency anaemia of childhood. Arch Dis Child. 1968 Apr;43(228):239–244. doi: 10.1136/adc.43.228.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heizer W. D., Laster L. Peptide hydrolase activities of the mucosa of human small intestine. J Clin Invest. 1969 Jan;48(1):210–228. doi: 10.1172/JCI105970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hirschfield J. S., Kern F., Jr Protein starvation and the small intestine. 3. Incorporation of orally and intraperitoneally administered 1-leucine 4,5-3H into intestinal mucosal protein of protein-deprived rats. J Clin Invest. 1969 Jul;48(7):1224–1229. doi: 10.1172/JCI106086. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Josefsson L., Lindberg T. Intestinal dipeptidases. I. Spectrophotometric determination and characterization of dipeptidase activity in pig intestinal mucosa. Biochim Biophys Acta. 1965 Jul 29;105(1):149–161. doi: 10.1016/s0926-6593(65)80183-7. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Lindberg T. Intestinal dipeptidases. Dipeptidase activity in the mucosa of the gastrointestinal tract of the adult human. Acta Physiol Scand. 1966 Apr;66(4):437–443. doi: 10.1111/j.1748-1716.1966.tb03221.x. [DOI] [PubMed] [Google Scholar]
- Lindberg T., Karlsson B. W. Changes in intestinal dipeptidase activities during fetal and neonatal development of the pig as related to the ultrastructure of mucosal cells. Gastroenterology. 1970 Aug;59(2):247–256. [PubMed] [Google Scholar]
- MOOG F., ORTIZ E. The functional differentiation of the small intestine. VII. The duodenum of the foetal guinea-pig, with a note on the growth of the adrenals. J Embryol Exp Morphol. 1960 Jun;8:182–197. [PubMed] [Google Scholar]
- PRETORIUS P. J., DE VILLIERS L. S. The effect of protein hydrolysate on initiation of cure and various biochemical indices of recovery in kwashiorkor. S Afr J Lab Clin Med. 1961 Sep;7:108–113. [PubMed] [Google Scholar]
- Peters T. J. Intestinal peptidases. Gut. 1970 Aug;11(8):720–725. doi: 10.1136/gut.11.8.720. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prinsloo J. G., Wittmann W., Pretorius P. J., Kruger H., Fellingham S. A. Effect of different sugars on diarrhoea of acute kwashiorkor. Arch Dis Child. 1969 Oct;44(237):593–599. doi: 10.1136/adc.44.237.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Solimano G., Burgess E. A., Levin B. Protein-calorie malnutrition: effect of deficient diets on enzyme levels of jejunal mucosa of rats. Br J Nutr. 1967;21(1):55–68. doi: 10.1079/bjn19670009. [DOI] [PubMed] [Google Scholar]
- Stanfield J. P., Hutt M. S., Tunnicliffe R. Intestinal biopsy in kwashiorkor. Lancet. 1965 Sep 11;2(7411):519–523. doi: 10.1016/s0140-6736(65)91474-1. [DOI] [PubMed] [Google Scholar]
- Wharton B., Howells G., Phillips I. Diarrhoea in kwashiorkor. Br Med J. 1968 Dec 7;4(5631):608–611. doi: 10.1136/bmj.4.5631.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
