Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1972 Apr;47(252):246–249. doi: 10.1136/adc.47.252.246

Blood Sugar Changes in Neonatal Hyperbilirubinaemia and Phenobarbitone Therapy

C Y Yeung
PMCID: PMC1648039  PMID: 5023473

Abstract

A controlled study was carried out to show the effect of bilirubinaemia and phenobarbitone therapy on the blood sugar metabolism in newborn infants. In the control infants, a significant inverse correlation existed between the serum bilirubin and the blood sugar levels in the first 4 days. The liver seemed to be a factor in producing such a relation. Glucose may be a useful adjunct to the treatment of neonatal hyperbilirubinaemia. Phenobarbitone therapy had significantly raised the blood sugar levels and lowered the serum bilirubin levels in these infants. It is suggested that enhancement of liver function or induction of hepatic enzymes may be the cause.

Full text

PDF
246

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILLING B. H., LATHE G. H. Bilirubin metabolism in jaundice. Am J Med. 1958 Jan;24(1):111–121. doi: 10.1016/0002-9343(58)90366-8. [DOI] [PubMed] [Google Scholar]
  2. BRAEHLER H. J., DALLENBACH-HELLWEG G. DIE LANGERHANSSCHEN INSELN BEI FETALER ERYTHROBLASTOSE. Virchows Arch Pathol Anat Physiol Klin Med. 1963 Aug 8;336:544–549. [PubMed] [Google Scholar]
  3. BURNS J. J. IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY. Am J Med. 1964 Sep;37:327–331. doi: 10.1016/0002-9343(64)90190-1. [DOI] [PubMed] [Google Scholar]
  4. Beutler E. A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency, and glutathione reductase deficiency. Blood. 1966 Oct;28(4):553–562. [PubMed] [Google Scholar]
  5. Blattner R. J. Central nervous system damage and hypoglycemia. J Pediatr. 1968 Jun;72(6):904–906. doi: 10.1016/s0022-3476(68)80447-0. [DOI] [PubMed] [Google Scholar]
  6. Catz C., Yaffe S. J. Barbiturate enhancement of bilirubin conjugation and excretion in young and adult animals. Pediatr Res. 1968 Sep;2(5):361–370. doi: 10.1203/00006450-196809000-00005. [DOI] [PubMed] [Google Scholar]
  7. Cornblath M., Joassin G., Weisskopf B., Swiatek K. R. Hypoglycemia in the newborn. Pediatr Clin North Am. 1966 Aug;13(3):905–920. [PubMed] [Google Scholar]
  8. Driscoll S. G., Steinke J. Pancreatic insulin content in severe erythroblastosis fetalis. Pediatrics. 1967 Mar;39(3):448–450. [PubMed] [Google Scholar]
  9. FRANCOIS R., PRADON M., SHERRER M., UGLIENGO A. R. Hypoglycemia due to pancreatic islet cell adenoma. J Pediatr. 1962 May;60:721–729. doi: 10.1016/s0022-3476(62)80099-7. [DOI] [PubMed] [Google Scholar]
  10. Levi A. J., Gatmaitan Z., Arias I. M. Deficiency of hepatic organic anion-binding protein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn. Lancet. 1969 Jul 19;2(7612):139–140. doi: 10.1016/s0140-6736(69)92444-1. [DOI] [PubMed] [Google Scholar]
  11. Price H. V. Hypoglycaemia complicating haemolytic disease of the newborn. Arch Dis Child. 1969 Apr;44(234):248–251. doi: 10.1136/adc.44.234.248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Raivio K. O., Osterlund K. Hypoglycemia and hyperinsulinemia associated with erythroblastosis fetalis. Pediatrics. 1969 Feb;43(2):217–225. [PubMed] [Google Scholar]
  13. Shelley H. J., Neligan G. A. Neonatal hypoglycaemia. Br Med Bull. 1966 Jan;22(1):34–39. doi: 10.1093/oxfordjournals.bmb.a070433. [DOI] [PubMed] [Google Scholar]
  14. Stern L., Khanna N. N., Levy G., Yaffe S. J. Effect of phenobarbital on hyperbilirubinemia and glucuronide formation in newborns. Am J Dis Child. 1970 Jul;120(1):26–31. doi: 10.1001/archpedi.1970.02100060060007. [DOI] [PubMed] [Google Scholar]
  15. Yeung C. Y., Field C. E. Phenobarbitone therapy in neonatal hyperbilirubinaemia. Lancet. 1969 Jul 19;2(7612):135–139. doi: 10.1016/s0140-6736(69)92443-x. [DOI] [PubMed] [Google Scholar]
  16. Yeung C. Y. Hypoglycemia in neonatal sepsis. J Pediatr. 1970 Nov;77(5):812–817. doi: 10.1016/s0022-3476(70)80240-2. [DOI] [PubMed] [Google Scholar]
  17. Yeung C. Y., Tam L. S., Chan A., Lee K. H. Phenobarbitone prophylaxis for neonatal hyperbilirubinemia. Pediatrics. 1971 Sep;48(3):372–376. [PubMed] [Google Scholar]
  18. Yeung C. Y., Yu V. Y. Phenobarbitone enhancement of bromsulphalein clearance in neonatal hyperbilirubinemia. Pediatrics. 1971 Oct;48(4):556–561. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES