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. 1972 Dec;47(256):954–959. doi: 10.1136/adc.47.256.954

Use of 5-Fluorocytosine in Systemic Candidiasis in Infancy

M Isacson, Z Noah, J Faber, Y Herishano, L Gottfried
PMCID: PMC1648422  PMID: 4630479

Abstract

Three cases of systemic candidiasis were successfully treated with 5-fluorocytosine (5-FC), an antifungal agent. The fungaemia developed during continuous intravenous alimentation for intestinal malabsorption. The diagnosis was confirmed by repeated positive cultures from blood, urine, and faeces. The fungus was also grown from cultures of intravenous solutions and catheters. The clinical features varied and included unexplained fever, oedema, stupor, tachypnoea, convulsions, hepatosplenomegaly, and congestive heart failure. The clinical symptoms receded rapidly and the cultures became negative after oral or intravenous treatment with 5-FC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boeckman C. R., Krill C. E., Jr Bacterial and fungal infections complicating parenteral alimentation in infants and children. J Pediatr Surg. 1970 Apr;5(2):117–126. doi: 10.1016/0022-3468(70)90267-8. [DOI] [PubMed] [Google Scholar]
  2. Cormane R. H., Goslings W. R. Factors influencing the growth of Candida albicans (in vivo and in vitro studies). Sabouraudia. 1963 Oct;3(1):52–63. [PubMed] [Google Scholar]
  3. Davies R. R., Reeves D. S. 5-fluorocytosine and urinary candidiasis. Br Med J. 1971 Mar 13;1(5749):577–579. doi: 10.1136/bmj.1.5749.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ellis C. A., Spivack M. L. The significance of candidemia. Ann Intern Med. 1967 Sep;67(3):511–522. doi: 10.7326/0003-4819-67-3-511. [DOI] [PubMed] [Google Scholar]
  5. Groff D. B. Complications of intravenous hyperalimentation in newborns and infants. J Pediatr Surg. 1969 Aug;4(4):460–464. doi: 10.1016/0022-3468(69)90614-9. [DOI] [PubMed] [Google Scholar]
  6. Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]
  7. Pepys J., Faux J. A., McCarthy D. S., Hargreave F. E. Candida albicans precipitins in respiratory disease in man. J Allergy. 1968 Jun;41(6):305–318. doi: 10.1016/0021-8707(68)90073-7. [DOI] [PubMed] [Google Scholar]
  8. Record C. O., Skinner J. M., Sleight P., Speller D. C. Candida endocarditis treated with 5-fluorocytosine. Br Med J. 1971 Jan 30;1(5743):262–264. doi: 10.1136/bmj.1.5743.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SKOBEL P., SCHABINSKI G., ESSIGKE G. Untersuchungen über die Immunitätslage und den Wert der Serodiagnostik bei Candida-Mykosen. Arztl Wochensch. 1956 Apr 6;11(14-15):317–320. [PubMed] [Google Scholar]
  10. Shadomy S. In vitro studies with 5-fluorocytosine. Appl Microbiol. 1969 Jun;17(6):871–877. doi: 10.1128/am.17.6.871-877.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Toala P., Schroeder S. A., Daly A. K., Finland M. Candida at Boston City Hospital. Clinical and epidemiological characteristics and susceptibility to eight antimicrobial agents. Arch Intern Med. 1970 Dec;126(6):983–989. doi: 10.1001/archinte.126.6.983. [DOI] [PubMed] [Google Scholar]

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