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. 1973 Jun;48(6):446–450. doi: 10.1136/adc.48.6.446

Effect of fatty acids on bilirubin conjugation

T Hargreaves
PMCID: PMC1648434  PMID: 4740270

Abstract

The effect of fatty acids on bilirubin conjugation has been studied. Unsaturated fatty acids containing 18 to 20 carbon atoms decreased the rate of conjugation in rat liver slices and microsomes, probably by inhibiting glucuronyl transferase. Since fatty acids may be an important source of energy for the young infant, the relation of these findings to breast milk jaundice is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIAS I. M., GARTNER L. M., SEIFTER S., FURMAN M. PROLONGED NEONATAL UNCONJUGATED HYPERBILIRUBINEMIA ASSOCIATED WITH BREAST FEEDING AND A STEROID, PREGNANE-3(ALPHA), 20(BETA)-DIOL, IN MATERNAL MILK THAT INHIBITS GLUCURONIDE FORMATION IN VITRO. J Clin Invest. 1964 Nov;43:2037–2047. doi: 10.1172/JCI105078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arthur L. J., Bevan B. R., Holton J. B. Neonatal hyperbilirubinaemia and breast feeding. Dev Med Child Neurol. 1966 Jun;8(3):279–284. doi: 10.1111/j.1469-8749.1966.tb01748.x. [DOI] [PubMed] [Google Scholar]
  3. Bevan B. R., Holton J. B. Inhibition of bilirubin conjugation in rat liver slices by free fatty acids, with relevance to the problem of breast milk jaundice. Clin Chim Acta. 1972 Oct;41:101–107. doi: 10.1016/0009-8981(72)90501-3. [DOI] [PubMed] [Google Scholar]
  4. Di Augustine R. P., Fouts J. R. The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450. Biochem J. 1969 Nov;115(3):547–554. doi: 10.1042/bj1150547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. György P. The uniqueness of human milk. Biochemical aspects. Am J Clin Nutr. 1971 Aug;24(8):970–975. doi: 10.1093/ajcn/24.8.970. [DOI] [PubMed] [Google Scholar]
  6. HARGREAVES T. THE ESTIMATION OF BILIRUBIN IN LIVER. Clin Chim Acta. 1965 Mar;11:278–280. doi: 10.1016/0009-8981(65)90075-6. [DOI] [PubMed] [Google Scholar]
  7. Hargreaves T. Breast-milk jaundice. Br Med J. 1970 Sep 12;3(5723):647–647. doi: 10.1136/bmj.3.5723.647-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hargreaves T., Piper R. F. Breast milk jaundice. Effect of inhibitory breast milk and 3 alpha, 20 abeta-pregnanediol on glucuronyl transferase. Arch Dis Child. 1971 Apr;46(246):195–198. doi: 10.1136/adc.46.246.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. INSULL W., Jr, AHRENS E. H., Jr The fatty acids of human milk from mothers on diets taken ad libitum. Biochem J. 1959 May;72(1):27–33. doi: 10.1042/bj0720027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LATHE G. H., WALKER M. The synthesis of bilirubin glucuronide in animal and human liver. Biochem J. 1958 Dec;70(4):705–712. doi: 10.1042/bj0700705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Levi A. J., Gatmaitan Z., Arias I. M. Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions. J Clin Invest. 1969 Nov;48(11):2156–2167. doi: 10.1172/JCI106182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Van Roy F. P., Heirwegh K. P. Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor. Biochem J. 1968 Apr;107(4):507–518. doi: 10.1042/bj1070507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wills E. D. Effects of lipid peroxidation on membrane-bound enzymes of the endoplasmic reticulum. Biochem J. 1971 Aug;123(5):983–991. doi: 10.1042/bj1230983. [DOI] [PMC free article] [PubMed] [Google Scholar]

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