Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1973 Jun;48(6):436–440. doi: 10.1136/adc.48.6.436

Cyclic chemotherapy in acute lymphoblastic leukaemia of childhood

5-Year survivals

M R Vowels, M L N Willoughby
PMCID: PMC1648451  PMID: 4514541

Abstract

Of 31 children with acute lymphoblastic leukaemia treated with a cyclical scheme of chemotherapy, 19% survived for over 5 years, 16% remained in continuing haematological remission for 5 years, and 13% remained leukaemia free for 5 years. These findings are relevant to potential cure, unlike the median remission duration, which is a measure of palliation.

A relation between the percentage of PAS-positive blast cells at diagnosis and duration of control of the disease still pertains for the long-term results in this series of patients.

Full text

PDF
436

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aur R. J., Simone J., Hustu H. O., Walters T., Borella L., Pratt C., Pinkel D. Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood. 1971 Mar;37(3):272–281. [PubMed] [Google Scholar]
  2. Bennett J. M., Henderson E. S. Lymphoblastic leukaemia. Br Med J. 1969 May 24;2(5655):513–513. doi: 10.1136/bmj.2.5655.513-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burchenal J. H. Long-term survivors in acute leukemia and Burkitt's tumor. Cancer. 1968 Apr;21(4):595–599. doi: 10.1002/1097-0142(196804)21:4<595::aid-cncr2820210408>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  4. George P., Hernandez K., Hustu O., Borella L., Holton C., Pinkel D. A study of "total therapy" of acute lymphocytic leukemia in children. J Pediatr. 1968 Mar;72(3):399–408. doi: 10.1016/s0022-3476(68)80217-3. [DOI] [PubMed] [Google Scholar]
  5. Holland J. F. E Pluribus Unum: Presidential address. Cancer Res. 1971 Oct;31(10):1319–1329. [PubMed] [Google Scholar]
  6. Krivit W., Gilchrist G., Beatty E. C., Jr The need for chemotherapy after prolonged complete remission in acute leukemia of childhood. J Pediatr. 1970 Jan;76(1):138–141. doi: 10.1016/s0022-3476(70)80147-0. [DOI] [PubMed] [Google Scholar]
  7. Laurie H. C. Duration of remissions in lymphoblastic leukaemia of childhood. Br Med J. 1968 Apr 13;2(5597):95–97. doi: 10.1136/bmj.2.5597.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pinkel D. Five-year follow-up of "total therapy" of childhood lymphocytic leukemia. JAMA. 1971 Apr 26;216(4):648–652. [PubMed] [Google Scholar]
  9. Saunders E. F., Kauder E., Mauer A. M. Sequential therapy of acute leukemia in childhood. J Pediatr. 1967 Apr;70(4):632–635. doi: 10.1016/s0022-3476(67)80053-2. [DOI] [PubMed] [Google Scholar]
  10. Sinks L. F. Treatment of acute lymphoblastic leukaemia. Arch Dis Child. 1972 Oct;47(255):811–813. doi: 10.1136/adc.47.255.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Willoughby M. L., Laurie H. C. Cyclic chemotherapy in childhood acute leukaemia. Arch Dis Child. 1968 Apr;43(228):187–194. doi: 10.1136/adc.43.228.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ZUELZER W. W. IMPLICATIONS OF LONG-TERM SURVIVAL IN ACUTE STEM CELL LEUKEMIA OF CHILDHOOD TREATED WITH COMPOSITE CYCLIC THERAPY. Blood. 1964 Nov;24:477–494. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES