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. 1974 Apr;49(4):278–282. doi: 10.1136/adc.49.4.278

Ascorbic acid in fetal human brain

B P F Adlard, S W De Souza, Susan Moon
PMCID: PMC1648749  PMID: 4830116

Abstract

Ascorbic acid concentrations in fetal human forebrain in the period 11 to 19 weeks' gestational age were 4 to 11 times higher than those of adults. Levels fell progressively with increasing gestational age but, in term babies dying within 4 weeks of birth, were still at least 3 times those of adults. It was confirmed that, in women delivering at term, ascorbic acid concentrations are approximately 4 times higher in cord blood plasma than in maternal blood plasma. The possible importance of ascorbic acid for normal human brain development is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adlard B. P., de Souza S. W., Moon S. The effect of age, growth retardation and asphyxia on ascorbic acid concentrations in developing brain. J Neurochem. 1973 Oct;21(4):877–881. doi: 10.1111/j.1471-4159.1973.tb07532.x. [DOI] [PubMed] [Google Scholar]
  2. Allison J. H., Stewart M. A. Myo-inositol and ascorbic acid in developing rat brain. J Neurochem. 1973 Jun;20(6):1785–1788. doi: 10.1111/j.1471-4159.1973.tb00296.x. [DOI] [PubMed] [Google Scholar]
  3. BURCH H. B. Methods for detecting and evaluating ascorbic acid deficiency in man and animals. Ann N Y Acad Sci. 1961 Apr 21;92:268–276. doi: 10.1111/j.1749-6632.1961.tb46125.x. [DOI] [PubMed] [Google Scholar]
  4. Battaglia F. C., Behrman R. E., Meschia G., Seeds A. E., Bruns P. D. Clearance of inert molecules, Na, and Cl ions across the primate placenta. Am J Obstet Gynecol. 1968 Dec 15;102(8):1135–1143. doi: 10.1016/0002-9378(68)90404-3. [DOI] [PubMed] [Google Scholar]
  5. Briggs M., Briggs M. Vitamin C and colds. Lancet. 1973 May 5;1(7810):998–998. doi: 10.1016/s0140-6736(73)91635-8. [DOI] [PubMed] [Google Scholar]
  6. Briggs M., Briggs M. Vitamin C requirements and oral contraceptives. Nature. 1972 Aug 4;238(5362):277–277. doi: 10.1038/238277a0. [DOI] [PubMed] [Google Scholar]
  7. Clemetson C. A. Caeruloplasmin and green plasma. Lancet. 1968 Nov 9;2(7576):1037–1037. doi: 10.1016/s0140-6736(68)91331-7. [DOI] [PubMed] [Google Scholar]
  8. Dancis J., Money W. L., Springer D., Levitz M. Transport of amino acids by placenta. Am J Obstet Gynecol. 1968 Jul 15;101(6):820–829. doi: 10.1016/0002-9378(68)90038-0. [DOI] [PubMed] [Google Scholar]
  9. Dobbing J., Sands J. Quantitative growth and development of human brain. Arch Dis Child. 1973 Oct;48(10):757–767. doi: 10.1136/adc.48.10.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dobbing J., Sands J. Timing of neuroblast multiplication in developing human brain. Nature. 1970 May 16;226(5246):639–640. doi: 10.1038/226639a0. [DOI] [PubMed] [Google Scholar]
  11. Edgar J. A. Dehydroascorbic acid and cell division. Nature. 1970 Jul 4;227(5253):24–26. doi: 10.1038/227024a0. [DOI] [PubMed] [Google Scholar]
  12. Enwonwu C. O. Alterations in ninhydrin-positive substances and cytoplasmic protein synthesis in the brains of ascorbic acid-deficient guinea pigs. J Neurochem. 1973 Jul;21(1):69–78. doi: 10.1111/j.1471-4159.1973.tb04226.x. [DOI] [PubMed] [Google Scholar]
  13. FAWCETT J. K., SCOTT J. E. A rapid and precise method for the determination of urea. J Clin Pathol. 1960 Mar;13:156–159. doi: 10.1136/jcp.13.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Frey M., Pitts B. J., Askari A. Vitamin C--effects on the Na+, K+ adenosine triphosphate phosphohydrolase complexes of several tissues. Biochem Pharmacol. 1973 Jan 1;22(1):9–15. doi: 10.1016/0006-2952(73)90249-9. [DOI] [PubMed] [Google Scholar]
  15. GOLDSMITH G. A. Human requirements for vitamin C and its use in clinical medicine. Ann N Y Acad Sci. 1961 Apr 21;92:230–245. doi: 10.1111/j.1749-6632.1961.tb46123.x. [DOI] [PubMed] [Google Scholar]
  16. Hughes R. E., Hurley R. J., Jones P. R. The retention of ascorbic acid by guinea-pig tissues. Br J Nutr. 1971 Nov;26(3):433–438. doi: 10.1079/bjn19710048. [DOI] [PubMed] [Google Scholar]
  17. Inagaki C. Inhibition of Mg- and Mg, Na, K-activated adenosine tgriphosphatase activity by L-ascorbic acid and L-cysteine. Jpn J Pharmacol. 1970 Mar;20(1):52–60. doi: 10.1254/jjp.20.52. [DOI] [PubMed] [Google Scholar]
  18. Izquierdo J. A., Jofré I. J., Acevedo C. The effect of ascorbic acid on the cerebral and adrenal catecholamine content in the male rat. J Pharm Pharmacol. 1968 Mar;20(3):210–214. doi: 10.1111/j.2042-7158.1968.tb09723.x. [DOI] [PubMed] [Google Scholar]
  19. KAUFMAN S., FRIEDMAN S. DOPAMINE-BETA-HYDROXYLASE. Pharmacol Rev. 1965 Jun;17:71–100. [PubMed] [Google Scholar]
  20. KNOX W. E., GOSWAMI M. N. Ascorbic acid in man and animals. Adv Clin Chem. 1961;4:121–205. doi: 10.1016/s0065-2423(08)60036-0. [DOI] [PubMed] [Google Scholar]
  21. KOFOED J. A., BLUMENKRANTZ N., HOUSSAY A. B., YAMAUCHI E. Y. CERVICAL MUCUS AND SERUM ASCORBIC AND DEHYDROASCORBIC ACID CONCENTRATIONS DURING THE MENSTRUAL CYCLE. Am J Obstet Gynecol. 1965 Jan 1;91:95–101. doi: 10.1016/0002-9378(65)90592-2. [DOI] [PubMed] [Google Scholar]
  22. LOWRY O. H. Biochemical evidence of nutritional status. Physiol Rev. 1952 Oct;32(4):431–448. doi: 10.1152/physrev.1952.32.4.431. [DOI] [PubMed] [Google Scholar]
  23. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  24. Longo L. D., Yuen P., Gusseck D. J. Anaerobic, glycogen-dependent transport of amino acids by the placenta. Nature. 1973 Jun 29;243(5409):531–533. doi: 10.1038/243531a0. [DOI] [PubMed] [Google Scholar]
  25. MARTIN M. P., BRIDGFORTH E., MCGANITY W. J., DARBY W. J. The Vanderbilt cooperative study of maternal and infant nutrition. X. Ascorbic acid. J Nutr. 1957 Jun 10;62(2):201–224. doi: 10.1093/jn/62.2.201. [DOI] [PubMed] [Google Scholar]
  26. RINALDINI L. M. Growth and ascorbic acid content of the chick embryo. J Embryol Exp Morphol. 1960 Dec;8:527–539. [PubMed] [Google Scholar]
  27. SHARMA S. K., JOHNSTONE R. M., QUASTEL J. H. Active transport of ascorbic acid in adrenal cortex and brain cortex in vitro and the effects of ACTH and steroids. Can J Biochem Physiol. 1963 Mar;41:597–604. [PubMed] [Google Scholar]
  28. Stone K. J., Townsley B. H. The effect of L-ascorbate on catecholamine biosynthesis. Biochem J. 1973 Mar;131(3):611–613. doi: 10.1042/bj1310611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sulkin D. F., Sulkin N. M., Nushan H. Fine structure of sensory ganglia during experimental scurvy. Acta Neuropathol. 1973 Jan 30;23(2):141–151. doi: 10.1007/BF00685768. [DOI] [PubMed] [Google Scholar]
  30. Tovey L. A., Lathe G. H. Caeruloplasmin and green plasma in women taking oral contraceptives, in pregnant women, and in patients with rheumatoid arthritis. Lancet. 1968 Sep 14;2(7568):596–600. [PubMed] [Google Scholar]
  31. WEATHERFORD T., Jr Morphological and histochemical studies on the autonomic ganglia of scorbutic guinea pigs. J Neuropathol Exp Neurol. 1961 Jul;20:440–449. doi: 10.1097/00005072-196107000-00007. [DOI] [PubMed] [Google Scholar]

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