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. 1974 Jul;49(7):505–515. doi: 10.1136/adc.49.7.505

Improved prognosis of infants mechanically ventilated for hyaline membrane disease

E O R Reynolds, A Taghizadeh
PMCID: PMC1648909  PMID: 4368797

Abstract

The results of mechanical ventilation for severe hyaline membrane disease (HMD), and the changes in technique which took place, during the 6-year period 1967-72 are described. A pilot study of the effect of hydrocortisone among the most severely affected infants showed no benefit. After the introduction at the beginning of 1970 of a regimen for ventilating the infants at low peak airway pressures, slow respiratory frequencies, and high inspiration: expiration ratios, there was a sudden increase in survival rate which was largely accounted for by a reduction in the incidence of bronchopulmonary dysplasia. Evidence is presented that in infants with HMD mechanical factors are more important than oxygen toxicity in the pathogenesis of this condition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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