Abstract
A trial of the effects of measures designed to reduce exposure to house-dust mites was performed on 14 children with mite-sensitive asthma. These measures reduced mite infestation of the beds and were associated with clinical improvement of asthmatic symptoms. Immunological studies revealed a tendency for levels of total serum IgE to fall during the course of the trial, but no such changes were apparent in the levels of anti-mite specific serum IgE. Possible reasons for this discrepancy are discussed.
The conclusion of the study is that the use of a plastic mattress cover and the other inexpensive and harmless avoidance measures described should be advised for all asthmatic children with evidence of mite-sensitivity before resort to drug prophylaxis or hyposensitization procedures.
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Selected References
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- Berg T., Johansson S. G. In vitro diagnosis of atopic allergy. IV. Seasonal variations of IgE antibodies in children allergic to pollens. Int Arch Allergy Appl Immunol. 1971;41(2):452–462. [PubMed] [Google Scholar]
- Hughes A. M., Maunsell K. A study of a population of house dust mite in its natural environment. Clin Allergy. 1973 Jun;3(2):127–131. doi: 10.1111/j.1365-2222.1973.tb01316.x. [DOI] [PubMed] [Google Scholar]
- Maunsell K., Hughes A. M., Wraith D. C. Mite asthma. Cause and management. Practitioner. 1970 Dec;205(230):779–783. [PubMed] [Google Scholar]
- Maunsell K., Wraith D. G., Cunnington A. M. Mites and house-dust allergy in bronchial asthma. Lancet. 1968 Jun 15;1(7555):1267–1270. doi: 10.1016/s0140-6736(68)92289-7. [DOI] [PubMed] [Google Scholar]
- McAllen M. K., Assem E. S., Maunsell K. House-dust mite asthma. Results of challenge tests on five criteria with Dermatophagoides pteronyssinus. Br Med J. 1970 May 30;2(5708):501–504. doi: 10.1136/bmj.2.5708.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowe D. S. Radioactive single radial diffusion: a method for increasing the sensitivity of immunochemical quantification of proteins in agar gel. Bull World Health Organ. 1969 Apr;40(4):613–616. [PMC free article] [PubMed] [Google Scholar]
- Sarsfield J. K. Role of house-dust mites in childhood asthma. Arch Dis Child. 1974 Sep;49(9):711–715. doi: 10.1136/adc.49.9.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stenius B., Wide L., Seymour W. M., Holford-Strevens V., Pepys J. Clinical significance of specific IgE to common allergens. I. Relationship of specific IgE against Dermatophagoides spp. and grass pollen to skin and nasal tests and history. Clin Allergy. 1971 Mar;1(1):37–55. doi: 10.1111/j.1365-2222.1971.tb02446.x. [DOI] [PubMed] [Google Scholar]
- VOORHORST R., SPIEKSMA-BOEZEMAN M. I., SPIEKSMA F. T. IS A MITE (DERMATOPHAGOIDES SP.) THE PRODUCER OF THE HOUSE-DUST ALLERGEN? Allerg Asthma (Leipz) 1964;10:329–334. [PubMed] [Google Scholar]
- Wharton G. W. Mites and commercial extracts of house dust. Science. 1970 Mar 6;167(3923):1382–1383. doi: 10.1126/science.167.3923.1382. [DOI] [PubMed] [Google Scholar]