Abstract
Impaired absorption of vitamin B12 has been shown by a whole body counter technique in 7 of 10 infants and children who had resection of over 45 cm of ileum. Absorption was normal in 2 patients who had 15 cm or more terminal ileum remaining. If absorption was abnormal the serum level of vitamin B12 did not fall below the lower limit of the normal range for several years, puberty being a particularly vulnerable time. Though the site and length of the resection often suggested whether vitamin B12 deficiency was likely to occur, an absorption test was necessary for accurate prediction and to allow treatment to be given rationally before complications occurred. The whole body counter technique was particularly suitable for children as it did not involve collection of urine or faeces, injections, or admission to hospital.
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Selected References
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- ANDERSON B. B. INVESTIGATIONS INTO THE EUGLENA METHOD FOR THE ASSAY OF THE VITAMIN B12 IN SERUM. J Clin Pathol. 1964 Jan;17:14–26. doi: 10.1136/jcp.17.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOOTH C. C. ABSORPTION FROM THE SMALL INTESTINE. Sci Basis Med Annu Rev. 1963:171–196. [PubMed] [Google Scholar]
- BOOTH C. C. The metabolic effects of intestinal resection in man. Postgrad Med J. 1961 Dec;37:725–739. doi: 10.1136/pgmj.37.434.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLARK A. C., BOOTH C. C. Deficiency of vitamin B12 after extensive resection of the distal small intestine in an infant. Arch Dis Child. 1960 Dec;35:595–599. doi: 10.1136/adc.35.184.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Callender S. T., Witts L. J., Warner G. T., Oliver R. The use of a simple whole-body counter for haematological investigations. Br J Haematol. 1966 May;12(3):276–282. doi: 10.1111/j.1365-2141.1966.tb05634.x. [DOI] [PubMed] [Google Scholar]
- DALLMAN P. R., DIAMOND L. K. Vitamin B12 deficiency associated with disease of the small intestine. Observations on an infant following extensive small bowel resection. J Pediatr. 1960 Nov;57:689–694. doi: 10.1016/s0022-3476(60)80162-x. [DOI] [PubMed] [Google Scholar]
- FONE D. J., COOKE W. T., MEYNELL M. J., HARRIS E. L. Co58B12 absorption (hepatic surface count) after gastrectomy, ileal resection, and in coeliac disorders. Gut. 1961 Sep;2:218–224. doi: 10.1136/gut.2.3.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HELGE H. [Vitamin B12 deficiency following ileal resection]. Monatsschr Kinderheilkd. 1963 Apr;111:131–138. [PubMed] [Google Scholar]
- Hoffbrand A. V., Newcombe F. A., Mollin D. L. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol. 1966 Jan;19(1):17–28. doi: 10.1136/jcp.19.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuffer F., Friolet B., Oetliker O., Bettex M. Darmfunktionsproben nach subtotaler Darmresektion bei einem Säugling. Helv Paediatr Acta. 1965 Apr;20(1):19–26. [PubMed] [Google Scholar]
- MOE P. J. INTESTINAL FUNCTION AFTER MASSIVE RESECTION OF THE SMALL INTESTINE IN A NEWBORN. Acta Paediatr. 1964 Nov;53:578–582. doi: 10.1111/j.1651-2227.1964.tb07270.x. [DOI] [PubMed] [Google Scholar]
- Valman H. B. Late vitamin B 12 deficiency following resection of the ileum in the neonatal period. Acta Paediatr Scand. 1972 Sep;61(5):561–564. doi: 10.1111/j.1651-2227.1972.tb15945.x. [DOI] [PubMed] [Google Scholar]
- WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]