Skip to main content
NCBI home page
American Journal of Public Health logoLink to American Journal of Public Health
. 1983 Oct;73(10):1204–1207. doi: 10.2105/ajph.73.10.1204

Validation of self-reported smoking behavior: biochemical analyses of cotinine and thiocyanate.

N J Haley, C M Axelrad, K A Tilton
PMCID: PMC1651081  PMID: 6614277

Abstract

Biochemical determinations of plasma and salivary cotinine and thiocyanate were used to differentiate smokers from non-smokers and to follow daily smoking patterns in smokers. Results indicate that cotinine is better suited than thiocyanate to determine smoking status in large scale epidemiologic studies and to follow alterations in smoking behavior over periods of time. Salivary cotinine is a reliable alternative to plasma for validation of smoking status and for following changes in daily smoking patterns.

Full text

PDF
1204

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Butts W. C., Kueheman M., Widdowson G. M. Automated method for determining serum thiocyanate, to distinguish smokers from nonsmokers. Clin Chem. 1974 Oct;20(10):1344–1348. [PubMed] [Google Scholar]
  2. Gillies P. A., Wilcox B., Coates C., Kristmundsdöttir F., Reid D. J. Use of objective measurement in the validation of self-reported smoking in children aged 10 and 11 years: saliva thiocyanate. J Epidemiol Community Health. 1982 Sep;36(3):205–208. doi: 10.1136/jech.36.3.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Herning R. I., Jones R. T., Bachman J., Mines A. H. Puff volume increases when low-nicotine cigarettes are smoked. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):187–189. doi: 10.1136/bmj.283.6285.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hill P., Marquardt H. Plasma and urine changes after smoking different brands of cigarettes. Clin Pharmacol Ther. 1980 May;27(5):652–658. doi: 10.1038/clpt.1980.92. [DOI] [PubMed] [Google Scholar]
  5. Hoffmann D., Adams J. D., Haley N. J. Reported cigarette smoke values: a closer look. Am J Public Health. 1983 Sep;73(9):1050–1053. doi: 10.2105/ajph.73.9.1050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hurd P. D., Johnson C. A., Pechacek T., Bast L. P., Jacobs D. R., Luepker R. V. Prevention of cigarette smoking in seventh grade students. J Behav Med. 1980 Mar;3(1):15–28. doi: 10.1007/BF00844911. [DOI] [PubMed] [Google Scholar]
  7. Langone J. J., Gjika H. B., Van Vunakis H. Nicotine and its metabolites. Radioimmunoassays for nicotine and cotinine. Biochemistry. 1973 Nov 20;12(24):5025–5030. doi: 10.1021/bi00748a032. [DOI] [PubMed] [Google Scholar]
  8. Luepker R. V., Pechacek T. F., Murray D. M., Johnson C. A., Hund F., Jacobs D. R. Saliva thiocyanate: a chemical indicator of cigarette smoking in adolescents. Am J Public Health. 1981 Dec;71(12):1320–1324. doi: 10.2105/ajph.71.12.1320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MALISZEWSKI T. F., BASS D. E. True and apparent thiocyanate in body fluids of smokers and nonsmokers. J Appl Physiol. 1955 Nov;8(3):289–291. doi: 10.1152/jappl.1955.8.3.289. [DOI] [PubMed] [Google Scholar]
  10. Ohlin P., Lundh B., Westling H. Carbon monoxide blood levels and reported cessation of smoking. Psychopharmacology (Berl) 1976 Sep 29;49(3):263–265. doi: 10.1007/BF00426827. [DOI] [PubMed] [Google Scholar]
  11. Vesey C. J., Saloojee Y., Cole P. V., Russell M. A. Blood carboxyhaemoglobin, plasma thiocyanate, and cigarette consumption: implications for epidemiological studies in smokers. Br Med J (Clin Res Ed) 1982 May 22;284(6328):1516–1518. doi: 10.1136/bmj.284.6328.1516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vogt T. M., Selvin S., Widdowson G., Hulley S. B. Expired air carbon monoxide and serum thiocyanate as objective measures of cigarette exposure. Am J Public Health. 1977 Jun;67(6):545–549. doi: 10.2105/ajph.67.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Williams C. L., Eng A., Botvin G. J., Hill P., Wynder E. L. Validation of students' self-reported cigarette smoking status with plasma cotinine levels. Am J Public Health. 1979 Dec;69(12):1272–1274. doi: 10.2105/ajph.69.12.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Williams C. L., Eng A., Botvin G. J., Hill P., Wynder E. L. Validation of students' self-reported cigarette smoking status with plasma cotinine levels. Am J Public Health. 1979 Dec;69(12):1272–1274. doi: 10.2105/ajph.69.12.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

RESOURCES