Abstract
About two-thirds of 90 clinics treating phenylketonuria (PKU) now recommend indefinite continuation of a low phenylalanine diet as compared to 1978 when fewer than one-fourth had this policy. The percentage of children maintained on diet has increased markedly for six to eight year-olds. Greater conservatism in clinic diet recommendations likely reflects reports of adverse consequences following diet discontinuation and negative individual clinic experiences.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BICKEL H., GERRARD J., HICKMANS E. M. Influence of phenylalanine intake on phenylketonuria. Lancet. 1953 Oct 17;265(6790):812–813. doi: 10.1016/s0140-6736(53)90473-5. [DOI] [PubMed] [Google Scholar]
- Brown E. S., Warner R. Mental development of phenylketonuric children on or off diet after the age of six. Psychol Med. 1976 May;6(2):287–296. doi: 10.1017/s0033291700013842. [DOI] [PubMed] [Google Scholar]
- Hauth J. C., Gilstrap L. C., 3rd, Widmer K. Fetal heart rate reactivity before and after maternal jogging during the third trimester. Am J Obstet Gynecol. 1982 Mar 1;142(5):545–547. doi: 10.1016/0002-9378(82)90758-x. [DOI] [PubMed] [Google Scholar]
- Koch R., Azen C. G., Friedman E. G., Williamson M. L. Preliminary report on the effects of diet discontinuation in PKU. J Pediatr. 1982 Jun;100(6):870–875. doi: 10.1016/s0022-3476(82)80503-9. [DOI] [PubMed] [Google Scholar]
- Lenke R. R., Levy H. L. Maternal phenylketonuria and hyperphenylalaninemia. An international survey of the outcome of untreated and treated pregnancies. N Engl J Med. 1980 Nov 20;303(21):1202–1208. doi: 10.1056/NEJM198011203032104. [DOI] [PubMed] [Google Scholar]
- Pueschel S. M., Fogelson-Doyle L., Kammerer B., Matsumiya Y. Neurophysiological, psychological, and nutritional investigations during discontinuation of the phenylalanine-restricted diet in children with classic phenylketonuria. J Ment Defic Res. 1983 Mar;27(Pt 1):61–67. doi: 10.1111/j.1365-2788.1983.tb00164.x. [DOI] [PubMed] [Google Scholar]
- Schuett V. E., Gurda R. F., Brown E. S. Diet discontinuation policies and practices of PKU clinics in the United States. Am J Public Health. 1980 May;70(5):498–503. doi: 10.2105/ajph.70.5.498. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waisbren S. E., Schnell R. R., Levy H. L. Diet termination in children with phenylketonuria: a review of psychological assessments used to determine outcome. J Inherit Metab Dis. 1980;3(4):149–153. doi: 10.1007/BF02312549. [DOI] [PubMed] [Google Scholar]
- Williamson M. L., Koch R., Azen C., Chang C. Correlates of intelligence test results in treated phenylketonuric children. Pediatrics. 1981 Aug;68(2):161–167. [PubMed] [Google Scholar]