Abstract
Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed.
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Selected References
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- Ames B. N., Kammen H. O., Yamasaki E. Hair dyes are mutagenic: identification of a variety of mutagenic ingredients. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2423–2427. doi: 10.1073/pnas.72.6.2423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ames B. N., Lee F. D., Durston W. E. An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc Natl Acad Sci U S A. 1973 Mar;70(3):782–786. doi: 10.1073/pnas.70.3.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bridges B. A. The three-tier approach to mutagenicity screening and the concept of radiation-equivalent dose. Mutat Res. 1974 Aug;26(4):335–340. doi: 10.1016/s0027-5107(74)80031-x. [DOI] [PubMed] [Google Scholar]
- Clive D. Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells. Mutat Res. 1974 Aug;26(4):307–318. doi: 10.1016/s0027-5107(74)80028-x. [DOI] [PubMed] [Google Scholar]
- Creech J. L., Jr, Johnson M. N. Angiosarcoma of liver in the manufacture of polyvinyl chloride. J Occup Med. 1974 Mar;16(3):150–151. [PubMed] [Google Scholar]
- Environmental mutagenic hazards. Science. 1975 Feb 14;187(4176):503–514. [PubMed] [Google Scholar]
- Flamm W. G. A tier system approach to mutagen testing. Mutat Res. 1974 Aug;26(4):329–333. doi: 10.1016/s0027-5107(74)80030-8. [DOI] [PubMed] [Google Scholar]
- McCann J., Choi E., Yamasaki E., Ames B. N. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135–5139. doi: 10.1073/pnas.72.12.5135. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Occupational disease among operating room personnel: a national study. Report of an Ad Hoc Committee on the Effect of Trace Anesthetics on the Health of Operating Room Personnel, American Society of Anesthesiologists. Anesthesiology. 1974 Oct;41(4):321–340. [PubMed] [Google Scholar]
- Papayannopoulou T. H., Mcguire T. C., Lim G., Garzel E., Nute P. E., Stamatoyannopoulos G. Identification of Haemoglobin S in red cells and normoblasts, using fluorescent anti-Hb S antibodies. Br J Haematol. 1976 Sep;34(1):25–31. doi: 10.1111/j.1365-2141.1976.tb00170.x. [DOI] [PubMed] [Google Scholar]
- de Serres F. J. Editorial: AF-2--food preservative or genetic hazard? Mutat Res. 1974 Feb;26(1):1–2. [PubMed] [Google Scholar]