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. 1991 Jan;1(1):11–15. doi: 10.1055/s-2008-1056973

Clinical Growth Rate of Acoustic Schwannomas

Correlation with the Growth Fraction as Defined by the Monoclonal Antibody Ki-67

T H J Lesser, R C Janzer, P Kleihues, U Fisch
PMCID: PMC1656299  PMID: 17170815

Abstract

The growth rate of acoustic tumors, although slow, varies widely. There may be a continuous spectrum or distinct groups of tumor growth rates. Clinical, audiologic, and conventional histologic tests have failed to shed any light on this problem. Modern immunohistochemical methods may stand a better chance. The Ki-67 monoclonal antibody stains proliferating cells and is used in this study to investigate the growth fraction of 13 skull base schwannomas. The acoustic tumors can be divided into two different growth groups, one with a rate five times the other. The literature is reviewed to see if this differentiation is borne out by the radiologic studies. Distinct growth rates have been reported: one very slow, taking 50 years to reach 1 cm in diameter, a second rate with a diameter increase of 0.2 cm/year, and a third rate five times the second, with a 1.0 cm increase in diameter per year. A fourth group growing at 2.5 cm/year is postulated, but these tumors cannot be followed for long radiologically, since symptoms demand surgical intervention. The clinical implications of these separate growth rates are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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