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. 2000 Jun 20;97(13):7657–7662. doi: 10.1073/pnas.97.13.7657

Figure 1.

Figure 1

(A) Effect of GAP-43 overexpression on acquisition of 1-min delayed nonmatching to sample (win-shift) task. Chance performance is slightly greater than four arm entries. The mean errors on trial 2 are compared among the groups. G-Phos animals, with phosphorylatable GAP-43, committed significantly fewer errors (ANOVA followed by individual t tests) than WT controls and G-NonP, overexpressing nonphosphorylatable GAP-43. (B) In the 20-min delay win-shift task, G-Phos mice performance was significantly superior to the other 3 mouse lines. (C) Effect of GAP-43 overexpression on delayed-matching to sample (win-stay) task. Mean days to criterion, two errors or fewer on 4 consecutive days, is compared among the groups. G-Phos animals required significantly fewer days to reach criterion than either G-Perm, overexpressing permanently pseudophosphorylated GAP-43, or WT controls. Errors were scored when the animal entered an arm other than the one baited arm. All groups, except G-NonP, began the task committing more errors than at chance level (for A-C, *, P < 0.05; **, P < 0.01; and ***, P < 0.001).