Abstract
STUDY OBJECTIVE--To study the association between cognitive impairment and early death in elderly patients living in the community. DESIGN--Case-control study of 410 patients assessed by the mental status questionnaire and followed up after three years. SETTING--A general practice in Inverurie, Aberdeenshire, with 14,000 patients. PATIENTS--205 Patients aged greater than or equal to 65 with cognitive impairment according to the mental status questionnaire (score less than or equal to 8) and 205 patients scoring greater than 8 on the questionnaire matched for age and sex. MAIN OUTCOME MEASURE--Death. RESULTS--The relative risk of death in the cognitively impaired patients overall was 3.5. Those patients who scored less than or equal to 7 on the mental status questionnaire were five times more likely to die than their controls. There was no difference in risk of death between those with severe or moderate cognitive impairment. CONCLUSIONS--Cognitive impairment is associated with early death.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anthony J. C., LeResche L., Niaz U., von Korff M. R., Folstein M. F. Limits of the 'Mini-Mental State' as a screening test for dementia and delirium among hospital patients. Psychol Med. 1982 May;12(2):397–408. doi: 10.1017/s0033291700046730. [DOI] [PubMed] [Google Scholar]
- Barclay L. L., Zemcov A., Blass J. P., Sansone J. Survival in Alzheimer's disease and vascular dementias. Neurology. 1985 Jun;35(6):834–840. doi: 10.1212/wnl.35.6.834. [DOI] [PubMed] [Google Scholar]
- Blessed G., Tomlinson B. E., Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968 Jul;114(512):797–811. doi: 10.1192/bjp.114.512.797. [DOI] [PubMed] [Google Scholar]
- Blessed G., Wilson I. D. The contemporary natural history of mental disorder in old age. Br J Psychiatry. 1982 Jul;141:59–67. doi: 10.1192/bjp.141.1.59. [DOI] [PubMed] [Google Scholar]
- Chandra V., Bharucha N. E., Schoenberg B. S. Conditions associated with Alzheimer's disease at death: case-control study. Neurology. 1986 Feb;36(2):209–211. doi: 10.1212/wnl.36.2.209. [DOI] [PubMed] [Google Scholar]
- Chandra V., Bharucha N. E., Schoenberg B. S. Patterns of mortality from types of dementia in the United States, 1971 and 1973-1978. Neurology. 1986 Feb;36(2):204–208. doi: 10.1212/wnl.36.2.204. [DOI] [PubMed] [Google Scholar]
- Christie A. B., Train J. D. Change in the pattern of care for the demented. Br J Psychiatry. 1984 Jan;144:9–15. doi: 10.1192/bjp.144.1.9. [DOI] [PubMed] [Google Scholar]
- Clarke M., Lowry R., Clarke S. Cognitive impairment in the elderly--a community survey. Age Ageing. 1986 Sep;15(5):278–284. doi: 10.1093/ageing/15.5.278. [DOI] [PubMed] [Google Scholar]
- Cooper B., Bickel H. Population screening and the early detection of dementing disorders in old age: a review. Psychol Med. 1984 Feb;14(1):81–95. doi: 10.1017/s0033291700003093. [DOI] [PubMed] [Google Scholar]
- Diesfeldt H. F., van Houte L. R., Moerkens R. M. Duration of survival in senile dementia. Acta Psychiatr Scand. 1986 Apr;73(4):366–371. doi: 10.1111/j.1600-0447.1986.tb02697.x. [DOI] [PubMed] [Google Scholar]
- Eagles J. M., Beattie J. A., Blackwood G. W., Restall D. B., Ashcroft G. W. The mental health of elderly couples. I. The effects of a cognitively impaired spouse. Br J Psychiatry. 1987 Mar;150:299–303. doi: 10.1192/bjp.150.3.299. [DOI] [PubMed] [Google Scholar]
- Eagles J. M., Craig A., Rawlinson F., Restall D. B., Beattie J. A., Besson J. A. The psychological well-being of supporters of the demented elderly. Br J Psychiatry. 1987 Mar;150:293–298. doi: 10.1192/bjp.150.3.293. [DOI] [PubMed] [Google Scholar]
- GUZE S. B., CANTWELL D. P. THE PROGNOSIS IN "ORGANIC BRAIN" SYNDROMES. Am J Psychiatry. 1964 Mar;120:878–881. doi: 10.1176/ajp.120.9.878. [DOI] [PubMed] [Google Scholar]
- Gilmore A. J. Some characteristics of non-surviving subjects in a three-year longitudinal study of elderly people living at home. Gerontol Clin (Basel) 1975;17(2):72–79. doi: 10.1159/000245560. [DOI] [PubMed] [Google Scholar]
- Go R. C., Todorov A. B., Elston R. C., Constantinidis J. The malignancy of dementias. Ann Neurol. 1978 Jun;3(6):559–561. doi: 10.1002/ana.410030620. [DOI] [PubMed] [Google Scholar]
- Goldfarb A. I. Predicting mortality in the institutionalized aged. A seven-year follow-up. Arch Gen Psychiatry. 1969 Aug;21(2):172–176. doi: 10.1001/archpsyc.1969.01740200044006. [DOI] [PubMed] [Google Scholar]
- Gurland B. J., Dean L. L., Copeland J., Gurland R., Golden R. Criteria for the diagnosis of dementia in the community elderly. Gerontologist. 1982 Apr;22(2):180–186. doi: 10.1093/geront/22.2.180. [DOI] [PubMed] [Google Scholar]
- Henderson A. S., Huppert F. A. The problem of mild dementia. Psychol Med. 1984 Feb;14(1):5–11. doi: 10.1017/s0033291700003020. [DOI] [PubMed] [Google Scholar]
- Hughes C. P., Berg L., Danziger W. L., Coben L. A., Martin R. L. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982 Jun;140:566–572. doi: 10.1192/bjp.140.6.566. [DOI] [PubMed] [Google Scholar]
- Ineichen B. Measuring the rising tide. How many dementia cases will there be by 2001? Br J Psychiatry. 1987 Feb;150:193–200. doi: 10.1192/bjp.150.2.193. [DOI] [PubMed] [Google Scholar]
- KAHN R. L., GOLDFARB A. I., POLLACK M., PECK A. Brief objective measures for the determination of mental status in the aged. Am J Psychiatry. 1960 Oct;117:326–328. doi: 10.1176/ajp.117.4.326. [DOI] [PubMed] [Google Scholar]
- KAY D. W., BEAMISH P., ROTH M. OLD AGE MENTAL DISORDERS IN NEWCASTLE UPON TYNE. I. A STUDY OF PREVALENCE. Br J Psychiatry. 1964 Mar;110:146–158. doi: 10.1192/bjp.110.465.146. [DOI] [PubMed] [Google Scholar]
- Libow L. S. Interaction of medical, biologic, and behavioral factors on aging, adaptation, and survival. An 11 year longitudinal study. Geriatrics. 1974 Nov;29(11):75–88. [PubMed] [Google Scholar]
- Martin D. C., Miller J. K., Kapoor W., Arena V. C., Boller F. A controlled study of survival with dementia. Arch Neurol. 1987 Nov;44(11):1122–1126. doi: 10.1001/archneur.1987.00520230012006. [DOI] [PubMed] [Google Scholar]
- Morgan K., Dallosso H. M., Arie T., Byrne E. J., Jones R., Waite J. Mental health and psychological well-being among the old and the very old living at home. Br J Psychiatry. 1987 Jun;150:801–807. doi: 10.1192/bjp.150.6.801. [DOI] [PubMed] [Google Scholar]
- Mölsä P. K., Marttila R. J., Rinne U. K. Survival and cause of death in Alzheimer's disease and multi-infarct dementia. Acta Neurol Scand. 1986 Aug;74(2):103–107. doi: 10.1111/j.1600-0404.1986.tb04634.x. [DOI] [PubMed] [Google Scholar]
- O'Connor D. W., Pollitt P. A., Hyde J. B., Brook C. P., Reiss B. B., Roth M. Do general practitioners miss dementia in elderly patients? BMJ. 1988 Oct 29;297(6656):1107–1110. doi: 10.1136/bmj.297.6656.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- POST F. The outcome of mental breakdown in old age. Br Med J. 1951 Mar 3;1(4704):436–440. doi: 10.1136/bmj.1.4704.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pfeffer R. I., Kurosaki T. T., Chance J. M., Filos S., Bates D. Use of the mental function index in older adults. Reliability, validity, and measurement of change over time. Am J Epidemiol. 1984 Dec;120(6):922–935. doi: 10.1093/oxfordjournals.aje.a113963. [DOI] [PubMed] [Google Scholar]
- ROTH M. The natural history of mental disorder in old age. J Ment Sci. 1955 Apr;101(423):281–301. doi: 10.1192/bjp.101.423.281. [DOI] [PubMed] [Google Scholar]
- Saugstad L. F., Odegård O. Mortality in psychiatric hospitals in Norway 1950--74. Acta Psychiatr Scand. 1979 Apr;59(4):431–447. doi: 10.1111/j.1600-0447.1979.tb04485.x. [DOI] [PubMed] [Google Scholar]
- Shah K. V., Banks G. D., Merskey H. Survival in atherosclerotic and senile dementia. Br J Psychiatry. 1969 Nov;115(528):1283–1286. doi: 10.1192/bjp.115.528.1283. [DOI] [PubMed] [Google Scholar]
- Shepherd M. Psychogeriatrics and the neo-epidemiologists. Psychol Med. 1984 Feb;14(1):1–4. doi: 10.1017/s0033291700003019. [DOI] [PubMed] [Google Scholar]
- Thompson P., Blessed G. Correlation between the 37-item mental test score and abbreviated 10-item mental test score by psychogeriatric day patients. Br J Psychiatry. 1987 Aug;151:206–209. doi: 10.1192/bjp.151.2.206. [DOI] [PubMed] [Google Scholar]
- Whitehead A., Hunt A. Elderly psychiatric patients: a five-year prospective study. Psychol Med. 1982 Feb;12(1):149–157. doi: 10.1017/s0033291700043403. [DOI] [PubMed] [Google Scholar]
- Wilson L. A., Brass W. Brief assessment of the mental state in geriatric domiciliary practice. The usefulness of the mental status questionnaire. Age Ageing. 1973 May;2(2):92–101. doi: 10.1093/ageing/2.2.92. [DOI] [PubMed] [Google Scholar]
