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. 1990 Mar 24;300(6727):774–777. doi: 10.1136/bmj.300.6727.774

Cryptosporidiosis in England and Wales: prevalence and clinical and epidemiological features. Public Health Laboratory Service Study Group.

PMCID: PMC1662540  PMID: 2322738

Abstract

In a two year study carried out by 16 public health laboratories in England and Wales 62,421 patients with presumed infective diarrhoea were investigated. Cryptosporidium infection was identified in 2% (1295), ranging from 0.5% to 3.9% among laboratories. The positivity rate for cryptosporidium was highest in 1-4 year olds, and in children cryptosporidium was the second commonest pathogen after campylobacter. Illness was usually limited to abdominal cramps and watery diarrhoea with six motions/24 hours at worst and lasting seven days. Fewer than half the patients reported fever or vomiting. More severe illness with fever, abdominal cramps, vomiting, and watery diarrhoea of frequency greater than five motions in 24 hours was reported by only a tenth of cases but with a significantly increased prevalence in young adult males. One hundred and fifty five patients (12%) probably acquired their infection abroad; 102 (9%) of patients who acquired their infection at home reported drinking raw milk in the month before onset, and 253 (22%) reported close contact with farm animals. Most laboratories experienced sudden infrequent increases in incidence in the community, only one of which was attributed to a recognised outbreak, which occurred in a nursery. Cryptosporidium should be routinely sought by laboratories investigating acute infectious diarrhoea, especially in children; up to a quarter of cases may be directly zoonotic, and the remainder may be due to person to person spread and waterborne infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bannister P., Mountford R. A. Cryptosporidium in the elderly: a cause of life-threatening diarrhea. Am J Med. 1989 Apr;86(4):507–508. doi: 10.1016/0002-9343(89)90366-5. [DOI] [PubMed] [Google Scholar]
  2. Baxby D., Hart C. A. The incidence of cryptosporidiosis: a two-year prospective survey in a children's hospital. J Hyg (Lond) 1986 Feb;96(1):107–111. doi: 10.1017/s0022172400062598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Casemore D. P., Armstrong M., Sands R. L. Laboratory diagnosis of cryptosporidiosis. J Clin Pathol. 1985 Dec;38(12):1337–1341. doi: 10.1136/jcp.38.12.1337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Casemore D. P., Jessop E. G., Douce D., Jackson F. B. Cryptosporidium plus Campylobacter: an outbreak in a semi-rural population. J Hyg (Lond) 1986 Feb;96(1):95–105. doi: 10.1017/s0022172400062586. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Casemore D. Cryptosporidiosis: another source. BMJ. 1989 Mar 18;298(6675):750–751. doi: 10.1136/bmj.298.6675.750-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Current W. L., Reese N. C., Ernst J. V., Bailey W. S., Heyman M. B., Weinstein W. M. Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N Engl J Med. 1983 May 26;308(21):1252–1257. doi: 10.1056/NEJM198305263082102. [DOI] [PubMed] [Google Scholar]
  7. D'Antonio R. G., Winn R. E., Taylor J. P., Gustafson T. L., Current W. L., Rhodes M. M., Gary G. W., Jr, Zajac R. A. A waterborne outbreak of cryptosporidiosis in normal hosts. Ann Intern Med. 1985 Dec;103(6 ):886–888. doi: 10.7326/0003-4819-103-6-886. [DOI] [PubMed] [Google Scholar]
  8. Hayes E. B., Matte T. D., O'Brien T. R., McKinley T. W., Logsdon G. S., Rose J. B., Ungar B. L., Word D. M., Pinsky P. F., Cummings M. L. Large community outbreak of cryptosporidiosis due to contamination of a filtered public water supply. N Engl J Med. 1989 May 25;320(21):1372–1376. doi: 10.1056/NEJM198905253202103. [DOI] [PubMed] [Google Scholar]
  9. Hunt D. A., Shannon R., Palmer S. R., Jephcott A. E. Cryptosporidiosis in an urban community. Br Med J (Clin Res Ed) 1984 Sep 29;289(6448):814–816. doi: 10.1136/bmj.289.6448.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Isaac-Renton J. L., Fogel D., Stibbs H. H., Ongerth J. E. Giardia and Cryptosporidium in drinking water. Lancet. 1987 Apr 25;1(8539):973–974. doi: 10.1016/s0140-6736(87)90313-8. [DOI] [PubMed] [Google Scholar]
  11. Jokipii L., Pohjola S., Jokipii A. M. Cryptosporidium: a frequent finding in patients with gastrointestinal symptoms. Lancet. 1983 Aug 13;2(8346):358–361. doi: 10.1016/s0140-6736(83)90341-0. [DOI] [PubMed] [Google Scholar]
  12. Lo Cascio V., Adami S., Galvanini G., Cominacini L., Scuro L. A. The time course of a hypercalcaemic crisis in acute primary hyperparathyroidism. Lancet. 1984 Mar 31;1(8379):735–736. doi: 10.1016/s0140-6736(84)92246-3. [DOI] [PubMed] [Google Scholar]
  13. McLauchlin J., Casemore D. P., Harrison T. G., Gerson P. J., Samuel D., Taylor A. G. Identification of cryptosporidium oocysts by monoclonal antibody. Lancet. 1987 Jan 3;1(8523):51–51. doi: 10.1016/s0140-6736(87)90753-7. [DOI] [PubMed] [Google Scholar]
  14. Navin T. R., Juranek D. D. Cryptosporidiosis: clinical, epidemiologic, and parasitologic review. Rev Infect Dis. 1984 May-Jun;6(3):313–327. doi: 10.1093/clinids/6.3.313. [DOI] [PubMed] [Google Scholar]
  15. Nime F. A., Burek J. D., Page D. L., Holscher M. A., Yardley J. H. Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology. 1976 Apr;70(4):592–598. [PubMed] [Google Scholar]
  16. Ribeiro C. D., Palmer S. R. Family outbreak of cryptosporidiosis. Br Med J (Clin Res Ed) 1986 Feb 8;292(6517):377–377. doi: 10.1136/bmj.292.6517.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Skirrow M. B. A demographic survey of campylobacter, salmonella and shigella infections in England. A Public Health Laboratory Service Survey. Epidemiol Infect. 1987 Dec;99(3):647–657. doi: 10.1017/s0950268800066504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Smith H. V., Girdwood R. W., Patterson W. J., Hardie R., Green L. A., Benton C., Tulloch W., Sharp J. C., Forbes G. I. Waterborne outbreak of cryptosporidiosis. Lancet. 1988 Dec 24;2(8626-8627):1484–1484. doi: 10.1016/s0140-6736(88)90951-8. [DOI] [PubMed] [Google Scholar]
  19. Thomson M. A., Benson J. W., Wright P. A. Two year study of cryptosporidium infection. Arch Dis Child. 1987 Jun;62(6):559–563. doi: 10.1136/adc.62.6.559. [DOI] [PMC free article] [PubMed] [Google Scholar]

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