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. 1990 Sep 8;301(6750):473–476. doi: 10.1136/bmj.301.6750.473

Adrenaline and nocturnal asthma.

J F Morrison 1, C Teale 1, S B Pearson 1, P Marshall 1, N M Dwyer 1, S Jones 1, H G Dean 1
PMCID: PMC1663754  PMID: 2207401

Abstract

OBJECTIVE--To determine whether the nocturnal fall in plasma adrenaline is a cause of nocturnal asthma. DESIGN--Double blind placebo controlled cross-over study. In the first experiment the nocturnal fall in plasma adrenaline at 4 am was corrected in 10 asthmatic subjects with an infusion of adrenaline after parasympathetic blockade with 30 micrograms/kg intravenous atropine. In the second experiment 11 asthmatic subjects showing similar variations in peak expiratory flow rate had the nocturnal fall in plasma adrenaline corrected by infusion before atropine was given. PATIENTS--Asthmatic subjects with a diurnal variation in home peak expiratory flow rate of greater than 20% for at least 75% of the time in the two weeks before the study. MAIN OUTCOME MEASURES--Peak expiratory flow rate and plasma adrenaline. RESULTS--Correction of the nocturnal fall in plasma adrenaline at 4 am to resting 4 pm levels did not alter peak expiratory flow rate either before or after parasympathetic blockade with atropine. CONCLUSION--A nighttime fall in plasma adrenaline is not a cause of nocturnal asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes P., FitzGerald G., Brown M., Dollery C. Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. N Engl J Med. 1980 Jul 31;303(5):263–267. doi: 10.1056/NEJM198007313030506. [DOI] [PubMed] [Google Scholar]
  2. Berkin K. E., Inglis G. C., Ball S. G., Thomson N. C. Airway responses to low concentrations of adrenaline and noradrenaline in normal subjects. Q J Exp Physiol. 1985 Apr;70(2):203–209. doi: 10.1113/expphysiol.1985.sp002903. [DOI] [PubMed] [Google Scholar]
  3. Berkin K. E., Inglis G. C., Ball S. G., Thomson N. C. Effect of low dose adrenaline and noradrenaline infusions on airway calibre in asthmatic patients. Clin Sci (Lond) 1986 Apr;70(4):347–352. doi: 10.1042/cs0700347. [DOI] [PubMed] [Google Scholar]
  4. Boschetto P., Roberts N. M., Rogers D. F., Barnes P. J. Effect of antiasthma drugs on microvascular leakage in guinea pig airways. Am Rev Respir Dis. 1989 Feb;139(2):416–421. doi: 10.1164/ajrccm/139.2.416. [DOI] [PubMed] [Google Scholar]
  5. Catterall J. R., Rhind G. B., Stewart I. C., Whyte K. F., Shapiro C. M., Douglas N. J. Effect of sleep deprivation on overnight bronchoconstriction in nocturnal asthma. Thorax. 1986 Sep;41(9):676–680. doi: 10.1136/thx.41.9.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chen W. Y., Chai H. Airway cooling and nocturnal asthma. Chest. 1982 Jun;81(6):675–680. doi: 10.1378/chest.81.6.675. [DOI] [PubMed] [Google Scholar]
  7. Da Prada M., Zürcher Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci. 1976 Oct 15;19(8):1161–1174. doi: 10.1016/0024-3205(76)90251-4. [DOI] [PubMed] [Google Scholar]
  8. Fitzgerald G. A., Barnes P., Hamilton C. A., Dollery C. T. Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man. Eur J Clin Invest. 1980 Oct;10(5):401–406. doi: 10.1111/j.1365-2362.1980.tb00052.x. [DOI] [PubMed] [Google Scholar]
  9. Hetzel M. R., Clark T. J. Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax. 1980 Oct;35(10):732–738. doi: 10.1136/thx.35.10.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Morice A., Sever P., Ind P. Adrenaline, bronchoconstriction, and asthma. Br Med J (Clin Res Ed) 1986 Aug 30;293(6546):539–540. doi: 10.1136/bmj.293.6546.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Morrison J. F., Pearson S. B., Dean H. G. Parasympathetic nervous system in nocturnal asthma. Br Med J (Clin Res Ed) 1988 May 21;296(6634):1427–1429. doi: 10.1136/bmj.296.6634.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Morrison J. F., Pearson S. B. The effect of the circadian rhythm of vagal activity on bronchomotor tone in asthma. Br J Clin Pharmacol. 1989 Nov;28(5):545–549. doi: 10.1111/j.1365-2125.1989.tb03540.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ollerenshaw S., Jarvis D., Woolcock A., Sullivan C., Scheibner T. Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma. N Engl J Med. 1989 May 11;320(19):1244–1248. doi: 10.1056/NEJM198905113201904. [DOI] [PubMed] [Google Scholar]

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