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. 1971 Jul;42(3):352–363. doi: 10.1111/j.1476-5381.1971.tb07119.x

Factors affecting the action of guanethidine on adrenergic neurones

O D Gulati, Saroja Jaykar
PMCID: PMC1665656  PMID: 5560897

Abstract

1. The uptake of guanethidine by adrenergic neurones has been studied indirectly by testing the ability of various procedures to prevent or reverse adrenergic neurone blockade in the periarterially stimulated isolated ileum preparation.

2. Adrenergic neurone blockade was prevented but not reversed by equilibration with guanethidine (3·3 × 10-6M) at low temperatures (10° C), in the absence of sodium or in the presence of tetrodotoxin (0·3 × 10-6M) or noradrenaline (1·2 × 10-3M).

3. Calcium (5 × 10-2M) both prevented and, to some extent, reversed the adrenergic neurone blocking action of guanethidine.

4. Equilibration with guanethidine in the presence of mersalyl (0·6 × 10-7M) or in the absence of potassium or calcium could neither prevent nor reverse adrenergic neurone blockade.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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