Abstract
1. The cervical sympathetic trunk of the isolated rat superior cervical ganglion was stimulated with short bursts of repetitive pulses. At room temperature with rates of stimulation of 4 Hz and above, the ganglionic action potentials were reduced in size.
2. Amphetamine (2·7 × 10-5M), which caused some depression of transmission during stimulation at 0·1 Hz, caused a partial reversal of the depression of transmission occurring with rates of stimulation above 4 Hz.
3. This action of amphetamine was mimicked by adrenaline (3 × 10-5M) and noradrenaline (9·6 × 10-5M) but not by isoprenaline (1·8 × 10-5M) and was unaffected by propranolol (1·4 × 10-5M) but was abolished by prior application of phenoxybenzamine (5·8 × 10-6M). Furthermore, this action of amphetamine was unaltered in ganglia taken from rats pretreated with reserpine (single dose of 6 mg/kg, 16 h before dissection).
4. Amphetamine had no effect on the surface potentials of the ganglion or on changes in these potentials produced by concentrations of carbachol (5· × 10-6M to 5·5 × 10-3M).
5. It is concluded that amphetamine has a direct action on α-adrenoceptors situated at presynaptic sites.
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Selected References
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