Abstract
1. Oral administration of berberine to infant rabbits 18-24 h before the intraintestinal administration of choleragenic toxins, arrests diarrhoea or significantly prolongs the survival time.
2. The use of berberine in the treatment of clinical cholera is further justified.
3. Berberine is an antidiarrhoeal drug and the host tissues play a major part in the control of diarrhoeal symptoms.
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Selected References
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- Amin A. H., Subbaiah T. V., Abbasi K. M. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol. 1969 Sep;15(9):1067–1076. doi: 10.1139/m69-190. [DOI] [PubMed] [Google Scholar]
- Bhide M. B., Chavan S. R., Dutta N. K. Absorption, distribution and excretion of berberine. Indian J Med Res. 1969 Nov;57(11):2128–2131. [PubMed] [Google Scholar]
- FINKELSTEIN R. A., NORRIS H. T., DUTTA N. K. PATHOGENESIS EXPERIMENTAL CHOLERA IN INFANT RABBITS. I. OBSERVATIONS ON THE INTRAINTESTINAL INFECTION AND EXPERIMENTAL CHOLERA PRODUCED WITH CELL-FREE PRODUCTS. J Infect Dis. 1964 Jun;114:203–216. doi: 10.1093/infdis/114.3.203. [DOI] [PubMed] [Google Scholar]
- Lahiri S. C., Dutta N. K. Berberine and chloramphenicol in the treatment of cholera and severe diarrhoea. J Indian Med Assoc. 1967 Jan 1;48(1):1–11. [PubMed] [Google Scholar]
- Mekawi M. Effect of berberine alkaloid on cholera Vibro and its endotoxin. J Egypt Med Assoc. 1966;49(8):554–559. [PubMed] [Google Scholar]
- Modak M. J., Modak S. M., Venkataraman A. Effect of berberine on the fatty acid composition of Vibrio cholerae and Vibrio cholerae biotype eltor. Indian J Med Res. 1970 Nov;58(11):1523–1527. [PubMed] [Google Scholar]
- Modak S., Modak M. J., Venkataraman A. Mechanism of action of berberine on Vibrio cholerae and vibrio cholerae biotype eltor. Indian J Med Res. 1970 Nov;58(11):1510–1522. [PubMed] [Google Scholar]
- Nair S., Modak M. J., Venkataraman A. Vibriostatic action of berberine. Indian J Pathol Bacteriol. 1967 Oct;10(4):389–391. [PubMed] [Google Scholar]
- Oza N. B., Dutta N. K. EXPERIMENTAL CHOLERA PRODUCED BY TOXIN PREPARED BY ULTRASONIC DISINTEGRATION OF VIBRIO COMMA. J Bacteriol. 1963 Feb;85(2):497–498. doi: 10.1128/jb.85.2.497-498.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sharda D. C. Berberine in the treatment of diarrhoea of infancy and childhood. J Indian Med Assoc. 1970 Jan 1;54(1):22–24. [PubMed] [Google Scholar]
- Subbaiah T. V., Amin A. H. Effect of berberine sulphate on Entamoeba histolytica. Nature. 1967 Jul 29;215(5100):527–528. doi: 10.1038/215527a0. [DOI] [PubMed] [Google Scholar]