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. 1972 Jan;44(1):52–62. doi: 10.1111/j.1476-5381.1972.tb07237.x

Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901)

B J Alps, Madeline Hill, E S Johnson, A B Wilson
PMCID: PMC1665700  PMID: 4401308

Abstract

1. Indoramin is a competitive α-adrenoceptor blocking agent on the guinea-pig isolated vas deferens and aortic strip; the pA2 value on the aorta is 7·4.

2. Indoramin is devoid of β-adrenoceptor blocking activity on the guinea-pig isolated trachea (10-4M) and the Langendorff preparation of the rabbit heart (10-6M). It also has no adrenergic neurone blocking action on the Finkleman preparation of the rabbit small intestine (10-5M).

3. On the Langendorff preparation of the rabbit isolated heart, indoramin (above 10-6M) has cardio-inhibitory properties similar to those of propranolol.

4. On the guinea-pig isolated ileum (10-5M) and trachea (10-6M), indoramin is devoid of anticholinergic activity, but has a potent antihistamine action which satisfies the criteria for competitive antagonism; the pA2 value for this antagonism on the ileum is 8·2.

5. Indoramin antagonizes 5-hydroxytryptamine on the rat isolated fundus and ileum; the pA2 value for the antagonism on the ileum is 6·0.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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