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. 1971 Dec;43(4):834–844. doi: 10.1111/j.1476-5381.1971.tb07220.x

Relationship between internal Na+/K+ and the accumulation of 14C-5-hydroxytryptamine by rat platelets

J M Sneddon
PMCID: PMC1665702  PMID: 5152030

Abstract

1. 5-Hydroxytryptamine (5-HT) transport has been investigated in rat blood platelets poisoned with dinitrophenol-sodium fluoride or ouabain.

2. The inhibition of transport produced by different concentrations of the metabolic inhibitors has been correlated with changes in the internal Na+ and K+ concentrations of the platelets.

3. Platelets poisoned in a high K+ medium maintained a high internal K+ concentration in the absence of cellular metabolism. When transferred to Krebs solutions containing different concentrations of Na+ they accumulated 5-HT by a process that was related to the magnitudes of the internal and external Na+ concentrations.

4. The results are consistent with the hypothesis that the spontaneous movement of ions through the platelet membrane is capable of providing, at least in part, the energy requirements for 5-HT transport.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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