Abstract
A single dose of α-methyl-p-tyrosine induced catalepsy in rats, commencing 6 h after administration. This catalepsy was strongly enhanced by (+)-amphetamine and (-)-ephedrine, but was antagonized by other amphetamine-like drugs. The implication of these findings is briefly discussed.
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Selected References
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- Bédard P., Larochelle L., Poirier L. J., Sourkes T. L. Reversible effect of L-dopa on tremor and catatonia induced by alpha-methyl-p-tyrosine. Can J Physiol Pharmacol. 1970 Jan;48(1):82–84. doi: 10.1139/y70-013. [DOI] [PubMed] [Google Scholar]
- Corrodi H., Fuxe K., Hökfelt T. The effect of some psychoactive drugs on central monoamine neurons. Eur J Pharmacol. 1967 Sep;1(5):363–368. doi: 10.1016/0014-2999(67)90096-9. [DOI] [PubMed] [Google Scholar]
- Randrup A., Munkvad I. Role of catecholamines in the amphetamine excitatory response. Nature. 1966 Jul 30;211(5048):540–540. doi: 10.1038/211540a0. [DOI] [PubMed] [Google Scholar]
- Scheel-Krüger J. Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur J Pharmacol. 1971;14(1):47–59. doi: 10.1016/0014-2999(71)90121-x. [DOI] [PubMed] [Google Scholar]
- Weissman A., Koe B. K. Behavioral effects of L-alpha-methyltyrosine, an inhibitor of tyrosine hydroxylase. Life Sci. 1965 May;4(10):1037–1048. doi: 10.1016/0024-3205(65)90223-7. [DOI] [PubMed] [Google Scholar]
- Weissman A., Koe B. K., Tenen S. S. Antiamphetamine effects following inhibition of tyrosine hydroxylase. J Pharmacol Exp Ther. 1966 Mar;151(3):339–352. [PubMed] [Google Scholar]
