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. 1971 Dec;43(4):732–738. doi: 10.1111/j.1476-5381.1971.tb07208.x

Effect of p-nitromethylamphetamine on biogenic amines and their amino-acid precursors in rat brain

B E Leonard, Susan A Shallice
PMCID: PMC1665720  PMID: 5152025

Abstract

1. Low doses of p-nitromethylamphetamine caused small increases in the concentrations of brain noradrenaline and dopamine in the rat; a dose of 60 mg/kg however, caused a decrease in the concentrations of both amines. p-Nitromethylamphetamine caused behavioural hyperexcitability only at doses which approximated to half the LD50 (68 mg/kg).

2. p-Nitromethylamphetamine potentiated the action of 4,α-dimethyl-m-tyramine in depleting brain noradrenaline. This suggests that it may affect brain noradrenaline concentrations by utilizing a reserpine resistant uptake mechanism.

3. p-Nitromethylamphetamine decreased the concentration of brain 5-hydroxytryptamine.

4. Changes in the blood and brain concentrations of tyrosine and γ-amino-n-butyric acid concentration in the brain could not be correlated with the changes in brain amines. However, a rise in the concentration of brain tryptophan appeared to be correlated with the fall in brain 5-hydroxytryptamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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