Abstract
1. Morphine, oxotremorine and physostigmine showed antinociceptive activity in mice using the hot plate reaction time test.
2. The action of morphine, but not that of oxotremorine, was antagonized by naloxone and by nalorphine, whereas the effect of physostigmine was unaffected by naloxone and increased by nalorphine.
3. The antinociceptive effects of morphine and of physostigmine were increased by procedures reported to increase the ratio of 5-hydroxytryptamine to dopamine in the brain. It was decreased by procedures reported to cause a fall in brain 5-hydroxytryptamine or a rise in dopamine relative to 5-hydroxytryptamine.
4. The antinociceptive effect of oxotremorine was potentiated by procedures reported to decrease brain noradrenaline and was unaffected by procedures altering brain 5-hydroxytryptamine.
5. The results suggest differences in the mode of action of morphine and physostigmine on the one hand and of oxotremorine on the other.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bousfield J. D., Rees J. M. The analgesic and respiratory depressant activities of N-allyl noretrophine and morphine in the mouse. J Pharm Pharmacol. 1969 Sep;21(9):630–632. doi: 10.1111/j.2042-7158.1969.tb08337.x. [DOI] [PubMed] [Google Scholar]
- CHEN G. The anti-tremorine effect of some drugs as determined by Haffner's method of testing analgesia in mice. J Pharmacol Exp Ther. 1958 Sep;124(1):73–76. [PubMed] [Google Scholar]
- Carlsson A., Lindqvist M., Fuxe K., Hökfelt T. Histochemical amd biochemical effects of diethyldithiocarbamate on tissue catecholamines. J Pharm Pharmacol. 1966 Jan;18(1):60–62. doi: 10.1111/j.2042-7158.1966.tb07773.x. [DOI] [PubMed] [Google Scholar]
- Fennessy M. R., Lee J. R. Modification of morphine analgesia by drugs affecting adrenergic and tryptaminergic mechanisms. J Pharm Pharmacol. 1970 Dec;22(12):930–935. doi: 10.1111/j.2042-7158.1970.tb08475.x. [DOI] [PubMed] [Google Scholar]
- Harris L. S., Dewey W. L., Howes J. F., Kennedy J. S., Pars H. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969 Sep;169(1):17–22. [PubMed] [Google Scholar]
- Ireson J. D. A comparison of the antinociceptive actions of cholinomimetic and morphine-like drugs. Br J Pharmacol. 1970 Sep;40(1):92–101. doi: 10.1111/j.1476-5381.1970.tb10614.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koe B. K., Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J Pharmacol Exp Ther. 1966 Dec;154(3):499–516. [PubMed] [Google Scholar]
- Lotti V. J., Porter C. C. Potentiation and inhbition of some central actions of L(-)-dopa by decarboxylase inhibitors. J Pharmacol Exp Ther. 1970 Apr;172(2):406–415. [PubMed] [Google Scholar]
- Major C. T., Pleuvry B. J. Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse. Br J Pharmacol. 1971 Aug;42(4):512–521. doi: 10.1111/j.1476-5381.1971.tb07137.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sethy V. H., Naik S. R., Sheth U. K. The effect of drugs influencing amine synthesis on the analgesic action of tremorine. Psychopharmacologia. 1971;19(1):73–80. doi: 10.1007/BF00403705. [DOI] [PubMed] [Google Scholar]
- Somerville A. R., Whittle B. A. The interrelation of hypothermia and depletion of noradrenaline, dopamine and 5-hydroxytryptamine from brain by reserpine, para-chlorophenylalanine and alpha-methylmetatyrosine. Br J Pharmacol Chemother. 1967 Sep;31(1):120–131. doi: 10.1111/j.1476-5381.1967.tb01982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spector S. Inhibitors of endogenous catecholamine biosynthesis. Pharmacol Rev. 1966 Mar;18(1):599–609. [PubMed] [Google Scholar]