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. 1971 Aug;42(4):497–504. doi: 10.1111/j.1476-5381.1971.tb07135.x

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

R S Grewal, C L Kaul
PMCID: PMC1665745  PMID: 5116034

Abstract

1. Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain.

2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries.

3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them.

4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment.

5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment.

6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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