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. 1971 Nov;43(3):504–513. doi: 10.1111/j.1476-5381.1971.tb07181.x

Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine

D A Hutchins, K J Rogers
PMCID: PMC1665784  PMID: 4400527

Abstract

1. Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25-30% after 30 minutes.

2. The effect of several receptor blocking drugs on the amphetamine-induced cerebral glycogenolysis was studied.

3. DL-Propranolol (0·25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine.

4. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine-induced glycogenolysis.

5. D-Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.

6. It is concluded that amphetamine-induced glycogenolysis in the mouse brain may be mediated through a β-adrenoceptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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