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. 1971 Nov;43(3):612–623. doi: 10.1111/j.1476-5381.1971.tb07191.x

Actions of quazodine (MJ1988) on smooth muscle

J R Parratt, Eileen Winslow
PMCID: PMC1665786  PMID: 4333696

Abstract

1. Quazodine (MJ1988; 6,7-dimethoxy-4-ethyl-quinazoline) relaxed a variety of vascular and extravascular smooth muscle preparations and antagonized, non-competitively, several substances which contract smooth muscle.

2. This activity was not due to β-adrenoceptor stimulation or to α-adrenoceptor blockade.

3. On the rabbit duodenum, the inhibitory effect was qualitatively similar to that of theophylline and was antagonized by the phosphodiesterase potentiator, imidazole.

4. The activity of quazodine was similar to, but up to 18 times greater than, that of theophylline and it is suggested that at least part of its activity on vascular and extravascular smooth muscle is due to inhibition of phosphodiesterase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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