Abstract
End-plate potentials (e.p.p.) and responses to ionophoretic application of acetylcholine (ACh potentials) have been recorded in frog muscle. Saxitoxin (STX) and tetrodotoxin (TTX) abolished the e.p.p. at concentrations of 10-8 g/ml. In almost all cases there was no effect on the ACh potentials even when the concentrations were raised, STX to 1·2 × 10-6 g/ml (3·2 × 1O-6M), or TTX to 5 × 10-6 g/ml (1·5 × 10-5M). STX, 10-6 g/ml (2·7 × 10-6M) often caused a slow rise in the frequency of miniature e.p.p., without significant effect on amplitude.
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Selected References
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